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Urocanic acid (UCA) is a major chromophore for ultraviolet (UV) radiation in the skin. On UV exposure, the naturally occurring trans-isomer converts to the cis-isomer in a dose-dependent manner. Accumulating evidence indicates that cis-UCA acts as an initiator of the UV-induced suppression of certain skin immune functions. This immunomodulation is recognized as an important factor in the development of skin cancer. In this study, pigmentation and UCA isomers were measured in 29 patients with previous basal cell carcinoma (BCC), 23 patients with previous cutaneous malignant melanoma (MM), and 32 healthy controls. Measurements were performed on UV-exposed (forehead, upper back) and UV non-exposed (buttock) skin. No significant differences in pigmentation percentage, total UCA concentration, relative (%) or absolute (nmol/cm2) cis-UCA concentration were observed between the groups in any of the body sites studied. The net production of cis-UCA after irradiation with a single test UV dose was evaluated. The relative production of cis-UCA following irradiation was significantly higher in both cancer groups when compared with the control group, while no significant difference was found between the BCC and the MM patients.
F De Fine Olivarius, and
J Lock-Andersen, and
F G Larsen, and
H C Wulf, and
J Crosby, and
M Norval
May 1999,
Acta dermato-venereologica,
F De Fine Olivarius, and
J Lock-Andersen, and
F G Larsen, and
H C Wulf, and
J Crosby, and
M Norval
April 2001,
The British journal of dermatology,
F De Fine Olivarius, and
J Lock-Andersen, and
F G Larsen, and
H C Wulf, and
J Crosby, and
M Norval
July 2018,
Proceedings (Baylor University. Medical Center),
F De Fine Olivarius, and
J Lock-Andersen, and
F G Larsen, and
H C Wulf, and
J Crosby, and
M Norval
January 1998,
Pathology, research and practice,
F De Fine Olivarius, and
J Lock-Andersen, and
F G Larsen, and
H C Wulf, and
J Crosby, and
M Norval
December 2021,
Archives of dermatological research,
F De Fine Olivarius, and
J Lock-Andersen, and
F G Larsen, and
H C Wulf, and
J Crosby, and
M Norval
January 2011,
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie,
F De Fine Olivarius, and
J Lock-Andersen, and
F G Larsen, and
H C Wulf, and
J Crosby, and
M Norval
October 2019,
Dermatologic clinics,
F De Fine Olivarius, and
J Lock-Andersen, and
F G Larsen, and
H C Wulf, and
J Crosby, and
M Norval
November 1996,
Histopathology,
F De Fine Olivarius, and
J Lock-Andersen, and
F G Larsen, and
H C Wulf, and
J Crosby, and
M Norval
February 1999,
The British journal of dermatology,
F De Fine Olivarius, and
J Lock-Andersen, and
F G Larsen, and
H C Wulf, and
J Crosby, and
M Norval
June 2000,
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.],
