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If information is stored as activity-driven increases in synaptic weights in the hippocampal formation, saturation of hippocampal long-term potentiation (LTP) should impair learning. Here, rats in which one hippocampus had been lesioned were implanted with a multielectrode stimulating array across and into the angular bundle afferent to the other hippocampus. Repeated cross-bundle tetanization caused cumulative potentiation. Residual synaptic plasticity was assessed by tetanizing a naïve test electrode in the center of the bundle. Spatial learning was disrupted in animals with no residual LTP (<10 percent) but not in animals that were capable of further potentiation. Thus, saturation of hippocampal LTP impairs spatial learning.
E I Moser, and
K A Krobert, and
M B Moser, and
R G Morris
April 1993,
Hippocampus,
E I Moser, and
K A Krobert, and
M B Moser, and
R G Morris
December 1999,
The Journal of neuroscience : the official journal of the Society for Neuroscience,
E I Moser, and
K A Krobert, and
M B Moser, and
R G Morris
June 1996,
Neuroscience letters,
E I Moser, and
K A Krobert, and
M B Moser, and
R G Morris
December 1992,
Science (New York, N.Y.),
E I Moser, and
K A Krobert, and
M B Moser, and
R G Morris
January 1992,
Cold Spring Harbor symposia on quantitative biology,
E I Moser, and
K A Krobert, and
M B Moser, and
R G Morris
November 1995,
Nature,
E I Moser, and
K A Krobert, and
M B Moser, and
R G Morris
March 2007,
The Journal of neuroscience : the official journal of the Society for Neuroscience,
E I Moser, and
K A Krobert, and
M B Moser, and
R G Morris
December 2019,
Neurobiology of learning and memory,
E I Moser, and
K A Krobert, and
M B Moser, and
R G Morris
January 1996,
Annual review of psychology,
E I Moser, and
K A Krobert, and
M B Moser, and
R G Morris
August 2014,
Anesthesiology,
