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Multidrug combination has been shown to be very useful to improve antitumor activity as well as to reduce the toxicity of different anti-cancer drugs. We have evaluated the interaction between the hypomethylating agent 5-azacytidine and the topoisomerase I and topoisomerase II inhibitors Camptothecin (CPT) and 4'-(9-acridinylamino) methanesulfon-m-anisidide (m-AMSA) respectively, based on the hypothesis that through the alteration of chromosome replication timing following DNA hypomethylation, the number of replication forks in early S phase might increase, so enhancing the probability of a collision between a blocked cleavable complex (DNA-topo I-CPT or DNA-topo II-m-AMSA) and a replication fork. We have tested the capacity of CPT and m-AMSA to induce chromosomal aberrations as well as reproductive cell death in synchronous cultured Chinese hamster ovary cells after a pretreatment with 5-azacytidine with positive results.
M López-Baena, and
S Mateos, and
J Piñero, and
Trinidad Ortiz, and
F Cortés
December 1999,
Mutation research,
M López-Baena, and
S Mateos, and
J Piñero, and
Trinidad Ortiz, and
F Cortés
August 1991,
Radiation research,
M López-Baena, and
S Mateos, and
J Piñero, and
Trinidad Ortiz, and
F Cortés
September 2017,
Oncotarget,
M López-Baena, and
S Mateos, and
J Piñero, and
Trinidad Ortiz, and
F Cortés
November 1984,
Somatic cell and molecular genetics,
M López-Baena, and
S Mateos, and
J Piñero, and
Trinidad Ortiz, and
F Cortés
August 1997,
Hepatology (Baltimore, Md.),
M López-Baena, and
S Mateos, and
J Piñero, and
Trinidad Ortiz, and
F Cortés
February 2008,
Experimental hematology,
M López-Baena, and
S Mateos, and
J Piñero, and
Trinidad Ortiz, and
F Cortés
January 1998,
Gerontology,
M López-Baena, and
S Mateos, and
J Piñero, and
Trinidad Ortiz, and
F Cortés
June 1981,
Nucleic acids research,
M López-Baena, and
S Mateos, and
J Piñero, and
Trinidad Ortiz, and
F Cortés
August 1976,
Biochemical pharmacology,
M López-Baena, and
S Mateos, and
J Piñero, and
Trinidad Ortiz, and
F Cortés
May 1982,
Journal of cellular physiology,
