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[Comparison of adjuvant chemotherapy in breast carcinoma with a combination of cyclophosphamide, methotrexate, 5-fluorouracil (CMF) and AC (doxorubicin, cyclophosphamide). Initial results of a national cooperative study]. 1998
O Pribylová, and
L Petruzelka, and
H Honová, and
J Fischer, and
I Bustová, and
H Siffnerová, and
M Kůta, and
V Miller, and
M Hacklová, and
J Machácek, and
M Kohoutek, and
P Vodvárka, and
T Kyselá, and
J Tajblová, and
J Suk, and
V Dorazilová, and
J Bauer
Onkologická klinika Vseobecné fakultní nemocnice v Praze a 1. lékarské fakulty Univerzity Karlovy, Praha.
The aim of this multicentric, prospective randomized trial is to evaluate and to compare, effects and toxicities of two chemotherapeutic combinations (AC and CMF) in adjuvant treatment of breast cancer. Both combinations were given in equitoxic doses and number of cycles was only four. There are 106 women treated for breast cancer T1c-3a, N0-1, M0 in the study. After surgery the patients were randomized, 54 for AC combination and 52 for CMF. We evaluate toxicity of this treatment in all patients in the study. Hematological and nonhematological side effects were comparable in both groups except alopecia (in the group AC was 100%). The study is not finished yet. Preliminary analysis does not show any difference between these two groups.
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