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We studied the sensitivity of human melanoma (Bro strain) xenografts to drugs of the nitrosoalkylurea (NAU) class: nitrosomethylurea (NMM), karmustin (BCNU), nimustin (ACNU), nitrulin, and ADEKO. High antitumor activity of NAM was shown when the drugs were applied not only at the early, but also at the late stages of tumor progression (tumor mass 400 and 1200 mg, respectively). The therapeutic effect of the drugs was estimated with the use of criteria characterizing the kinetics of tumor regression, increased life span, and survival of treated animals. After early administration of the drugs (Day 4 after tumor transplantation), 67% and 50% of animals survive under the influence of nitrulin and ACNU, respectively, while the rate of tumor regression increased in the sequence nitrulin < karmustin < NMM < ACNU. After late administration (11 days after tumor transplantation), NMM was most effective at increasing survival (35% of survived animals by 35 days of observation), while the rate of tumor regression increased in the sequence ADEKO < NMM < karmustin < nitrulin < ACNU.
L A Ostrovskaia, and
N M Ul'ianova, and
M M Fomina, and
V A Rykova, and
A A Konradov, and
E F Brin, and
N V Gorbunova
November 1994,
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology,
L A Ostrovskaia, and
N M Ul'ianova, and
M M Fomina, and
V A Rykova, and
A A Konradov, and
E F Brin, and
N V Gorbunova
September 1994,
Biulleten' eksperimental'noi biologii i meditsiny,
L A Ostrovskaia, and
N M Ul'ianova, and
M M Fomina, and
V A Rykova, and
A A Konradov, and
E F Brin, and
N V Gorbunova
January 1989,
Carcinogenesis; a comprehensive survey,
L A Ostrovskaia, and
N M Ul'ianova, and
M M Fomina, and
V A Rykova, and
A A Konradov, and
E F Brin, and
N V Gorbunova
October 1984,
Cancer research,
L A Ostrovskaia, and
N M Ul'ianova, and
M M Fomina, and
V A Rykova, and
A A Konradov, and
E F Brin, and
N V Gorbunova
January 1988,
Progress in clinical and biological research,
L A Ostrovskaia, and
N M Ul'ianova, and
M M Fomina, and
V A Rykova, and
A A Konradov, and
E F Brin, and
N V Gorbunova
December 1980,
International journal of cancer,
L A Ostrovskaia, and
N M Ul'ianova, and
M M Fomina, and
V A Rykova, and
A A Konradov, and
E F Brin, and
N V Gorbunova
August 1982,
Gan to kagaku ryoho. Cancer & chemotherapy,
L A Ostrovskaia, and
N M Ul'ianova, and
M M Fomina, and
V A Rykova, and
A A Konradov, and
E F Brin, and
N V Gorbunova
October 1991,
Biulleten' eksperimental'noi biologii i meditsiny,
L A Ostrovskaia, and
N M Ul'ianova, and
M M Fomina, and
V A Rykova, and
A A Konradov, and
E F Brin, and
N V Gorbunova
October 1992,
The Tohoku journal of experimental medicine,
L A Ostrovskaia, and
N M Ul'ianova, and
M M Fomina, and
V A Rykova, and
A A Konradov, and
E F Brin, and
N V Gorbunova
May 2008,
La Revue du praticien,
