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To investigate the effects of rebamipide, an antigastritis and anti-gastric ulcer drug, on inducible nitric oxide synthase (iNOS), murine macrophage RAW264.7 cells were treated with interferon-gamma (IFN-gamma) in the presence of rebamipide. NO production was stimulated by IFN-gamma, and the level was attenuated by rebamipide in a dose-dependent manner. Therefore, we investigated the possibility that either rebamipide directly inhibited iNOS enzyme activity or that it reduced iNOS mRNA expression. In a cell-free system, rebamipide did not affect iNOS enzyme activity; however, rebamipide inhibited iNOS mRNA and protein expression induced by IFN-gamma. Thus, we concluded that rebamipide inhibited IFN-gamma-induced NO production as a result of its inhibitory action on iNOS mRNA expression.
C Nagano, and
H Wakebe, and
A Azuma, and
K Imagawa, and
M Kikuchi
February 1994,
Biochemical and biophysical research communications,
C Nagano, and
H Wakebe, and
A Azuma, and
K Imagawa, and
M Kikuchi
January 2003,
The Journal of biological chemistry,
C Nagano, and
H Wakebe, and
A Azuma, and
K Imagawa, and
M Kikuchi
February 2001,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
C Nagano, and
H Wakebe, and
A Azuma, and
K Imagawa, and
M Kikuchi
May 2010,
Parasitology research,
C Nagano, and
H Wakebe, and
A Azuma, and
K Imagawa, and
M Kikuchi
January 2011,
International archives of allergy and immunology,
C Nagano, and
H Wakebe, and
A Azuma, and
K Imagawa, and
M Kikuchi
November 2008,
Archives of pharmacal research,
C Nagano, and
H Wakebe, and
A Azuma, and
K Imagawa, and
M Kikuchi
October 2008,
Veterinary immunology and immunopathology,
C Nagano, and
H Wakebe, and
A Azuma, and
K Imagawa, and
M Kikuchi
April 1995,
International immunology,
C Nagano, and
H Wakebe, and
A Azuma, and
K Imagawa, and
M Kikuchi
November 2006,
Journal of immunology (Baltimore, Md. : 1950),
C Nagano, and
H Wakebe, and
A Azuma, and
K Imagawa, and
M Kikuchi
February 2004,
Immunology letters,
