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Clinical conditions with low gastric acid secretion have been associated with increased risk of gastric cancer. There has also been concern about gastric acid inhibition and N-nitroso compound formation in the stomach. This study investigates the effect of gastric acid secretion on the penetration of N-3H-methyl-N-nitro-N-nitrosoguanidine, an N-nitroso compound and gastric carcinogen, into the gastric mucosa of rats. Gastric acid secretion was stimulated by pentagastrin (40 microg/kg/hr) and inhibited by omeprazole (40 micromol/kg) before mucosal exposure to N-3H-methyl-N-nitro-N-nitrosoguanidine. Penetration of the carcinogen was evaluated by light microscopic identification of cells in the S-phase labeled with N-3H-methyl-N-nitro-N-nitrosoguanidine. This population of double-labeled cells is considered at risk from N-methyl-N-nitro-N-nitrosoguanidine-induced carcinogenesis. The percentage of double-labeled cells was significantly higher in antrum than in corpus mucosa (P < 0.0001). Stimulation or inhibition of gastric acid secretion did not affect the penetration of N-3H-methyl-N-nitro-N-nitrosoguanidine in antrum or corpus mucosa. We conclude that modulation of gastric acid secretion does not affect the penetration of the carcinogen into the gastric mucosa nor does it explain the different penetration of the carcinogen into corpus and antrum mucosa.
K K Ovrebø, and
H Sørbye, and
S Kvinnsland, and
K Grong, and
K Svanes
July 1977,
Journal of the National Cancer Institute,
K K Ovrebø, and
H Sørbye, and
S Kvinnsland, and
K Grong, and
K Svanes
June 1978,
The American journal of digestive diseases,
K K Ovrebø, and
H Sørbye, and
S Kvinnsland, and
K Grong, and
K Svanes
April 1994,
Carcinogenesis,
K K Ovrebø, and
H Sørbye, and
S Kvinnsland, and
K Grong, and
K Svanes
January 1993,
Journal of cancer research and clinical oncology,
K K Ovrebø, and
H Sørbye, and
S Kvinnsland, and
K Grong, and
K Svanes
May 2002,
Japanese journal of cancer research : Gann,
K K Ovrebø, and
H Sørbye, and
S Kvinnsland, and
K Grong, and
K Svanes
March 2015,
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie,
K K Ovrebø, and
H Sørbye, and
S Kvinnsland, and
K Grong, and
K Svanes
April 1976,
Gan,
K K Ovrebø, and
H Sørbye, and
S Kvinnsland, and
K Grong, and
K Svanes
March 1985,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
K K Ovrebø, and
H Sørbye, and
S Kvinnsland, and
K Grong, and
K Svanes
September 1986,
Cancer research,
K K Ovrebø, and
H Sørbye, and
S Kvinnsland, and
K Grong, and
K Svanes
January 1979,
Neoplasma,
