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Several studies have shown that the morbidity risk for anxiety disorders is increased among the relatives of patients with obsessive-compulsive disorder (OCD). Recently, it was reported that a polymorphism of the catechol-O-methyltransferase (COMT) gene is significantly associated with OCD. The purpose of this study was to determine the association, if any, between the COMT polymorphism and anxiety disorders. We undertook an association study of the COMT polymorphism in 108 patients who met DSM-IV criteria for anxiety disorders and 135 healthy controls. All subjects were unrelated Japanese. The subdiagnostic groups did not differ significantly from the control group in either the genotypic or allelic frequencies. There were no statistically significant differences between the genotype and males, females, or a family history. The mean age of onset did not significantly differ among the genotypes. Our results suggest this functional COMT polymorphism does not make an important contribution to anxiety disorders in the Japanese population.
K Ohara, and
M Nagai, and
Y Suzuki, and
M Ochiai, and
K Ohara
January 2011,
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M Nagai, and
Y Suzuki, and
M Ochiai, and
K Ohara
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M Nagai, and
Y Suzuki, and
M Ochiai, and
K Ohara
September 2004,
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K Ohara, and
M Nagai, and
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M Ochiai, and
K Ohara
July 2010,
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K Ohara, and
M Nagai, and
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K Ohara
January 2006,
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K Ohara, and
M Nagai, and
Y Suzuki, and
M Ochiai, and
K Ohara
July 2004,
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K Ohara, and
M Nagai, and
Y Suzuki, and
M Ochiai, and
K Ohara
January 2005,
Neuropsychobiology,
K Ohara, and
M Nagai, and
Y Suzuki, and
M Ochiai, and
K Ohara
December 2008,
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,
K Ohara, and
M Nagai, and
Y Suzuki, and
M Ochiai, and
K Ohara
July 2012,
Psychiatry research,
K Ohara, and
M Nagai, and
Y Suzuki, and
M Ochiai, and
K Ohara
October 2014,
Diagnostic pathology,
