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The effects of alprazolam (1.5 mg/die) on the levels of the monoaminergic neurotransmitter metabolites, on the activity of the hypothalamic-pituitary-adrenal axis and on clinical outcome in subjects with primary late-onset dysthymia were investigated. Drug treatment significantly decreased plasma and urinary cortisol levels, serotonin platelet-bound and urinary 3-methoxy-4-hydroxyphenylglycol concentrations, while it increased plasma homovanillic acid (HVA) concentrations. Significant relationships were observed between neurochemicals and global scores or some items of the Hamilton Depression Rating Scale, before and after treatment. Patients responded positively (73%) to the therapy; clinical outcome was significantly correlated with plasma and urinary HVA levels. Collected data seem to support the hypothesis that central monoaminergic systems are in part involved in therapeutic response to alprazolam.
G Santagostino, and
M L Cucchi, and
P Frattini, and
F Zerbi, and
E Di Paolo, and
S Preda, and
G L Corona
January 2000,
Neurochemistry international,
G Santagostino, and
M L Cucchi, and
P Frattini, and
F Zerbi, and
E Di Paolo, and
S Preda, and
G L Corona
May 2019,
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience,
G Santagostino, and
M L Cucchi, and
P Frattini, and
F Zerbi, and
E Di Paolo, and
S Preda, and
G L Corona
January 1991,
Methods and findings in experimental and clinical pharmacology,
G Santagostino, and
M L Cucchi, and
P Frattini, and
F Zerbi, and
E Di Paolo, and
S Preda, and
G L Corona
February 1986,
Die Pharmazie,
G Santagostino, and
M L Cucchi, and
P Frattini, and
F Zerbi, and
E Di Paolo, and
S Preda, and
G L Corona
August 2007,
Stress (Amsterdam, Netherlands),
G Santagostino, and
M L Cucchi, and
P Frattini, and
F Zerbi, and
E Di Paolo, and
S Preda, and
G L Corona
November 1996,
Arzneimittel-Forschung,
G Santagostino, and
M L Cucchi, and
P Frattini, and
F Zerbi, and
E Di Paolo, and
S Preda, and
G L Corona
January 1984,
Clinical neuropathology,
G Santagostino, and
M L Cucchi, and
P Frattini, and
F Zerbi, and
E Di Paolo, and
S Preda, and
G L Corona
January 1990,
Neuropsychobiology,
G Santagostino, and
M L Cucchi, and
P Frattini, and
F Zerbi, and
E Di Paolo, and
S Preda, and
G L Corona
December 1998,
Brain research. Developmental brain research,
G Santagostino, and
M L Cucchi, and
P Frattini, and
F Zerbi, and
E Di Paolo, and
S Preda, and
G L Corona
February 2020,
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology,
