Ontogeny of hyperphagia in the Zucker (fa/fa) rat. 1998

T J Kowalski, and A M Ster, and G P Smith
E. W. Bourne Behavioral Research Laboratory, New York Hospital-Cornell Medical Center, White Plains, New York 10605, USA.

The ontogeny of hyperphagic behavior in the Zucker fatty (fa/fa) rat was examined. Wild-type, +/fa, and fa/fa pups aged postnatal day 5 (P5), P9, P12, P15, and P18 were evaluated using a test that measured ingestive behavior independent of the dam. The independent ingestive test consisted of giving pups access to a test solution [half-and-half (cream and milk)] on a tissue on the floor of a test chamber for 20 min. The latency to ingest and the intake (weight gain and percent weight gain) were measured and normalized to +/fa littermates. Pups were tested once to eliminate any effects of test experience. fa/fa Pups ingested significantly more than lean pups (+/+ and +/fa) on P12, P15, and P18, but not on P5 or P9. The latencies of fa/fa pups did not differ significantly from the latencies of +/+ pups except on P18, when the latencies of fa/fa pups were significantly shorter. The latencies of +/fa pups were significantly longer than the latencies of fa/fa or +/+ pups on P5 and P12. These results demonstrate that hyperphagia in fa/fa rats emerges between P9 and P12 under the test conditions used.

UI MeSH Term Description Entries
D006963 Hyperphagia Ingestion of a greater than optimal quantity of food. Overeating,Polyphagia,Polyphagias
D008297 Male Males
D009765 Obesity A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
D011924 Rats, Zucker Two populations of Zucker rats have been cited in research--the "fatty" or obese and the lean. The "fatty" rat (Rattus norvegicus) appeared as a spontaneous mutant. The obese condition appears to be due to a single recessive gene. Zucker Rat,Zucker Rats,Rat, Zucker
D001835 Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms. Body Weights,Weight, Body,Weights, Body
D005260 Female Females
D005838 Genotype The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS. Genogroup,Genogroups,Genotypes
D006579 Heterozygote An individual having different alleles at one or more loci regarding a specific character. Carriers, Genetic,Genetic Carriers,Carrier, Genetic,Genetic Carrier,Heterozygotes
D000375 Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time. Senescence,Aging, Biological,Biological Aging
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

T J Kowalski, and A M Ster, and G P Smith
April 1999, Appetite,
T J Kowalski, and A M Ster, and G P Smith
September 1979, Journal of lipid research,
T J Kowalski, and A M Ster, and G P Smith
September 1981, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
T J Kowalski, and A M Ster, and G P Smith
October 1999, Physiology & behavior,
T J Kowalski, and A M Ster, and G P Smith
May 1983, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
T J Kowalski, and A M Ster, and G P Smith
November 1981, Metabolism: clinical and experimental,
T J Kowalski, and A M Ster, and G P Smith
October 2010, Behavioural processes,
T J Kowalski, and A M Ster, and G P Smith
August 2005, American journal of physiology. Heart and circulatory physiology,
T J Kowalski, and A M Ster, and G P Smith
January 1998, Molecular and cellular endocrinology,
Copied contents to your clipboard!