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The results of the animal experiment demonstrate that oxidative hydroxylation is the major mode of metabolism of phencyclidine. It is evident that this process takes place in all three rings of the molecule. Hydroxylation of the piperidyl moiety probably also accounts for the formation of the N-dealkylated metabolites. Metabolism of phencyclidine in humans appears, at least in part, to be similar to that in the rat. Hydroxylation is still the principal mode in the case of humans though of a lesser extent. Metabolites hydroxylated in the phenyl moiety as well as dihydroxy derivatives of phencyclidine have so far not been observed in humans. Furthermore, most of the monohydroxy metabolites exist as conjugates in the human urine. It should also be pointed out that no metabolites have yet been detected in human blood samples.
L K Wong, and
K Biemann
January 1988,
Drug metabolism and disposition: the biological fate of chemicals,
L K Wong, and
K Biemann
January 1998,
Life sciences,
L K Wong, and
K Biemann
August 1982,
European journal of pharmacology,
L K Wong, and
K Biemann
May 1996,
Neuroscience letters,
L K Wong, and
K Biemann
May 1998,
Die Pharmazie,
L K Wong, and
K Biemann
September 1986,
The Journal of pharmacology and experimental therapeutics,
L K Wong, and
K Biemann
January 1980,
Journal of analytical toxicology,
L K Wong, and
K Biemann
September 1983,
Journal of chromatography,
L K Wong, and
K Biemann
January 1984,
Journal of analytical toxicology,
L K Wong, and
K Biemann
April 1987,
Pharmacology, biochemistry, and behavior,
