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BACKGROUND Proton-pump inhibitor therapy may cause false-negative results on Helicobacter pylori diagnostic testing. OBJECTIVE To determine the frequency and duration of conversion of urea breath test results from positive to negative in patients given a proton-pump inhibitor. METHODS Two urban university gastroenterology clinics. METHODS Patients infected with H. pylori who had positive results on urea breath tests. METHODS Lansoprazole, 30 mg/d for 28 days. METHODS The urea breath test was repeated at 28 days. If the results were negative, testing was repeated 3, 7, 14, and 28 days after completion of therapy until the results reverted to positive. RESULTS 31 (33%) of 93 patients in whom H. pylori was not eradicated had a negative breath test result while receiving lansoprazole. The proportions of patients whose breath test results were positive after completion of lansoprazole therapy were 91% (95% CI, 83% to 96%) at 3 days, 97% (CI, 90% to 99%) at 7 days, and 100% (CI, 96% to 100%) at 14 days. CONCLUSIONS Patients should not receive proton-pump inhibitors for 2 weeks before receiving the urea breath test for H. pylori infection.
L Laine, and
R Estrada, and
M Trujillo, and
K Knigge, and
M B Fennerty
April 2018,
European journal of internal medicine,
L Laine, and
R Estrada, and
M Trujillo, and
K Knigge, and
M B Fennerty
January 1992,
Scandinavian journal of gastroenterology,
L Laine, and
R Estrada, and
M Trujillo, and
K Knigge, and
M B Fennerty
February 2002,
Nihon rinsho. Japanese journal of clinical medicine,
L Laine, and
R Estrada, and
M Trujillo, and
K Knigge, and
M B Fennerty
January 2004,
Gut,
L Laine, and
R Estrada, and
M Trujillo, and
K Knigge, and
M B Fennerty
July 1997,
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology,
L Laine, and
R Estrada, and
M Trujillo, and
K Knigge, and
M B Fennerty
September 2006,
Basic & clinical pharmacology & toxicology,
L Laine, and
R Estrada, and
M Trujillo, and
K Knigge, and
M B Fennerty
January 2015,
Clinical interventions in aging,
L Laine, and
R Estrada, and
M Trujillo, and
K Knigge, and
M B Fennerty
September 2012,
Journal of clinical biochemistry and nutrition,
L Laine, and
R Estrada, and
M Trujillo, and
K Knigge, and
M B Fennerty
March 2003,
Methods and findings in experimental and clinical pharmacology,
L Laine, and
R Estrada, and
M Trujillo, and
K Knigge, and
M B Fennerty
March 2015,
Alimentary pharmacology & therapeutics,
