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The immunosuppressive effects of UV radiation have been well documented. This suppression has been attributed to the action of the cis form of urocanic acid (UCA), a photoproduct of trans-UCA, a natural constituent of the skin. Here, we show that mouse spleen cells preincubated with cis-UCA have a diminished proliferative response to allogeneic cells in MLC and to stimulation with anti-CD3 mAb. Cells preincubated with cis-UCA also had a decreased ability to serve as APC and to stimulate the proliferation of allogeneic lymphocytes in MLC. Simultaneously, the production of IL-2 and IFN-gamma by cells preincubated with cis-UCA was decreased. However, IL-10 gene expression and IL-10 protein secretion by spleen cells stimulated in the presence of cis-UCA were significantly enhanced. The principal cell population displaying the cis-UCA-induced elevated production of IL-10 was CD4+ T cells, which were shown to be a direct target of cis-UCA action. This was also supported by the observation that production of IL-10 by stimulated splenic non-T cells or by macrophages was not altered by cis-UCA. The enhanced production of IL-10 by activated CD4+ T cells may represent a novel pathway of UVB radiation-induced, cis-UCA-mediated immunosuppression. We suggest that the elevated production of IL-10 by activated CD4+ T cells may account for the suppressor T cell phenomena described in UV-irradiated recipients.
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P Holler, and
A Jancárek
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Bioscience, biotechnology, and biochemistry,
V Holán, and
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M Filipec, and
P Holler, and
A Jancárek
October 2010,
European journal of immunology,
V Holán, and
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August 1998,
Immunology,
V Holán, and
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August 2012,
European journal of immunology,
V Holán, and
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A Jancárek
February 1999,
Journal of immunology (Baltimore, Md. : 1950),
V Holán, and
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January 2014,
Polish journal of veterinary sciences,
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November 2011,
European journal of immunology,
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October 2013,
Journal of immunology (Baltimore, Md. : 1950),
V Holán, and
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A Jancárek
March 2001,
Journal of immunology (Baltimore, Md. : 1950),
