Biomaterial Database

Evidence for different 5-HT1B/1D receptors mediating vasoconstriction of equine digital arteries and veins. 1998

S R Bailey, and J Elliott

Department of Veterinary Basic Sciences, Royal Veterinary College, London, UK.

5-hydroxytryptamine (5-HT) is a potent vasoconstrictor of equine digital arteries and veins which may play a role in the ischaemic disease, laminitis. The present investigation compared the properties of 5-HT1B/1D receptors in arteries with those in veins using isolated rings of equine digital blood vessels. The 5-HT1B/1D receptor-selective agonists, anpirtoline and sumatriptan were 17.9 and 10 times more potent and produced 4.1 and 5.6 times greater maximum contractions, respectively, in veins when compared to arteries. Other agonists tested were of equal potency and produced the same maximum responses in veins and arteries. Propranolol competitively inhibited 5-HT1B/1D receptor mediated responses in arteries, with a pKB of 6.7, but had no significant effects on responses in veins at 1 microM. Metergoline competitively inhibited 5-HT1B/1D receptor mediated responses in veins, with a pKB of 8.1, but had no significant effect in arteries at 0.1 microM. These data suggest that 5-HT1B/1D receptors mediating vasoconstriction in equine digital arteries are pharmacologically different to those found in digital veins.

UI	MeSH Term	Description	Entries
D011985	Receptors, Serotonin	Cell-surface proteins that bind SEROTONIN and trigger intracellular changes which influence the behavior of cells. Several types of serotonin receptors have been recognized which differ in their pharmacology, molecular biology, and mode of action.	5-HT Receptor,5-HT Receptors,5-Hydroxytryptamine Receptor,5-Hydroxytryptamine Receptors,Receptors, Tryptamine,Serotonin Receptor,Serotonin Receptors,Tryptamine Receptor,Tryptamine Receptors,Receptors, 5-HT,Receptors, 5-Hydroxytryptamine,5 HT Receptor,5 HT Receptors,5 Hydroxytryptamine Receptor,5 Hydroxytryptamine Receptors,Receptor, 5-HT,Receptor, 5-Hydroxytryptamine,Receptor, Serotonin,Receptor, Tryptamine,Receptors, 5 HT,Receptors, 5 Hydroxytryptamine
D006614	Hindlimb	Either of two extremities of four-footed non-primate land animals. It usually consists of a FEMUR; TIBIA; and FIBULA; tarsals; METATARSALS; and TOES. (From Storer et al., General Zoology, 6th ed, p73)	Hindlimbs
D006736	Horses	Large, hoofed mammals of the family EQUIDAE. Horses are active day and night with most of the day spent seeking and consuming food. Feeding peaks occur in the early morning and late afternoon, and there are several daily periods of rest.	Equus caballus,Equus przewalskii,Horse, Domestic,Domestic Horse,Domestic Horses,Horse,Horses, Domestic
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001158	Arteries	The vessels carrying blood away from the heart.	Artery
D014661	Vasoconstriction	The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.	Vasoconstrictions
D014680	Veins	The vessels carrying blood away from the CAPILLARY BEDS.	Vein
D044302	Receptor, Serotonin, 5-HT1B	A serotonin receptor subtype found at high levels in the BASAL GANGLIA and the frontal cortex. It plays a role as a terminal autoreceptor that regulates the rate of SEROTONIN release from nerve endings. This serotonin receptor subtype is closely related to and has similar drug binding properties as the 5-HT1D RECEPTOR. It is particularly sensitive to the agonist SUMATRIPTAN and may be involved in mediating the drug's antimigraine effect.	Serotonin 1B Receptor,5-HT(1B) Receptor,5-HT(1Dbeta) Receptor,5-HT1B Receptor,5-HT1Dbeta Receptor,5-Hydroxytryptamine 1B Receptor,5-Hydroxytryptamine 1B Receptors,Receptor, 5-Hydroxytryptamine 1B,Receptor, Serotonin Type 1Dbeta,Serotonin 1D Beta Receptor,Serotonin 1Dbeta Receptor,Serotonin 1Dbeta Receptors,1B Receptor, 5-Hydroxytryptamine,1B Receptors, 5-Hydroxytryptamine,5 HT1B Receptor,5 HT1Dbeta Receptor,5 Hydroxytryptamine 1B Receptor,5 Hydroxytryptamine 1B Receptors,Receptor, 5 Hydroxytryptamine 1B,Receptor, 5-HT1B,Receptor, 5-HT1Dbeta,Receptor, Serotonin 1B,Receptor, Serotonin 1Dbeta,Receptors, 5-Hydroxytryptamine 1B,Receptors, Serotonin 1Dbeta
D044346	Receptor, Serotonin, 5-HT1D	A serotonin receptor subtype that is localized to the CAUDATE NUCLEUS; PUTAMEN; the NUCLEUS ACCUMBENS; the HIPPOCAMPUS, and the RAPHE NUCLEI. It plays a role as a terminal autoreceptor that regulates the rate of SEROTONIN release from nerve endings. This serotonin receptor subtype is closely related to and has similar drug binding properties as the 5-HT1B RECEPTOR, but is expressed at low levels. It is particularly sensitive to the agonist SUMATRIPTAN and may be involved in mediating the drug's antimigrane effect.	Serotonin 1D Receptor,5-HT(1D) Receptor,5-HT(1Dalpha) Receptor,5-HT1D Receptor,5-HT1Dalpha Receptor,5-Hydroxytryptamine1D Receptor,Receptor, Serotonin 1D,Receptor, Serotonin 1Dalpha,Serotonin 1D Alpha Receptor,Serotonin 1D Receptors,Serotonin 1Dalpha Receptor,Serotonin 1Dalpha Receptors,5 HT1D Receptor,5 Hydroxytryptamine1D Receptor,Receptor, 5-HT1D,Receptor, 5-Hydroxytryptamine1D,Receptors, Serotonin 1D
D018490	Serotonin Agents	Drugs used for their effects on serotonergic systems. Among these are drugs that affect serotonin receptors, the life cycle of serotonin, and the survival of serotonergic neurons.	Serotonergic Agents,Serotonergic Drugs,Serotonin Drugs,Serotonin Effect,Serotonin Effects,Serotoninergic Effect,Serotoninergic Effects,Agents, Serotonergic,Agents, Serotonin,Drugs, Serotonergic,Drugs, Serotonin,Effect, Serotonin,Effect, Serotoninergic,Effects, Serotonin,Effects, Serotoninergic