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The methylation status of 12 CpG sites in three exons of the human factor VIII (F8C) gene was examined by bisulphite genomic sequencing of human sperm DNA from 14 European Caucasians and Asians. Different CpG sites were found to vary in their methylation status both within and between individuals. Strand differences in methylation status were also detected at certain sites, a finding that could reflect hemi-methylation. No evidence for systematic deviations in methylation status were found between the two ethnic groups. Only a limited correlation was observed between the level of methylation of specific CpG sites in sperm DNA and their mutability, a finding that is probably attributable to the pattern of methylation observed in mature spermatocytes not being representative of that of the germline.
D S Millar, and
M Krawczak, and
D N Cooper
May 1991,
Nucleic acids research,
D S Millar, and
M Krawczak, and
D N Cooper
December 2001,
Human mutation,
D S Millar, and
M Krawczak, and
D N Cooper
January 2002,
Human mutation,
D S Millar, and
M Krawczak, and
D N Cooper
March 2002,
Human mutation,
D S Millar, and
M Krawczak, and
D N Cooper
January 2016,
Epigenetics,
D S Millar, and
M Krawczak, and
D N Cooper
September 2002,
Human mutation,
D S Millar, and
M Krawczak, and
D N Cooper
January 2013,
Methods in molecular biology (Clifton, N.J.),
D S Millar, and
M Krawczak, and
D N Cooper
September 2008,
Proceedings of the National Academy of Sciences of the United States of America,
D S Millar, and
M Krawczak, and
D N Cooper
May 1998,
Nucleic acids research,
D S Millar, and
M Krawczak, and
D N Cooper
June 1993,
The Biochemical journal,
