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Contribution of the interventricular septum to maximal right ventricular function. 1998

U Klima, and J L Guerrero, and G J Vlahakes
Department of Thoracic and Cardiovascular Surgery, Hannover Medical School, Medizinische Hochschule Hannover, Germany. klima@thg.mh-hannover.de

OBJECTIVE Maximal right ventricular (RV) function is influenced by left heart hemodynamics, possibly mediated by the interventricular scpturn (IVS). We examined the potential contribution of the IVS function to right heart function. METHODS In 12 canine isovolumic right heart preparations, incremental volumes were introduced into a high compliance RV balloon until RV failure occurred. Maximal RV developed pressure (RVDP) and maximal positive RV dP/dt were determined with a working IVS at a constant left ventricular (LV) output of 2 l/min and at a constant mean arterial pressure of 80 mmHg. Thereafter the IVS was thermally inactivated, and measurements were repeated using the same protocol. RESULTS At constant arterial pressure and constant LV output, thermal inactivation of the IVS led to a significant decrease in maximal RVDP (inactivated vs. working IVS: 36.1+/-9.8 vs. 56.8+/-16.2 mmHg, respectively, P < 0.001), and RV dP/dt (inactivated vs. working IVS: 720+/-220 vs. 1350+/-190 mmHg/s, respectively, P < 0.001). CONCLUSIONS These results suggest that the functional status of the IVS is a major determinant of maximal RV function. At constant LV conditions and arterial pressure, an inactivated IVS leads to a significant decrease in maximal RVDP and RV dP/dt under the conditions of this study.

UI MeSH Term Description Entries
D009200 Myocardial Contraction Contractile activity of the MYOCARDIUM. Heart Contractility,Inotropism, Cardiac,Cardiac Inotropism,Cardiac Inotropisms,Contractilities, Heart,Contractility, Heart,Contraction, Myocardial,Contractions, Myocardial,Heart Contractilities,Inotropisms, Cardiac,Myocardial Contractions
D004285 Dogs The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065) Canis familiaris,Dog
D006346 Heart Septum This structure includes the thin muscular atrial septum between the two HEART ATRIA, and the thick muscular ventricular septum between the two HEART VENTRICLES. Cardiac Septum,Heart Septa,Septa, Heart,Septum, Cardiac,Septum, Heart
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D016276 Ventricular Function The hemodynamic and electrophysiological action of the HEART VENTRICLES. Function, Ventricular,Functions, Ventricular,Ventricular Functions
D016278 Ventricular Function, Right The hemodynamic and electrophysiological action of the right HEART VENTRICLE. Right Ventricular Function,Function, Right Ventricular,Functions, Right Ventricular,Right Ventricular Functions,Ventricular Functions, Right
D017725 Ventricular Pressure The pressure within a CARDIAC VENTRICLE. Ventricular pressure waveforms can be measured in the beating heart by catheterization or estimated using imaging techniques (e.g., DOPPLER ECHOCARDIOGRAPHY). The information is useful in evaluating the function of the MYOCARDIUM; CARDIAC VALVES; and PERICARDIUM, particularly with simultaneous measurement of other (e.g., aortic or atrial) pressures. Intraventricular Pressure,Intraventricular Pressures,Pressure, Intraventricular,Pressure, Ventricular,Pressures, Intraventricular,Pressures, Ventricular,Ventricular Pressures

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