Biomaterial Database

Cobalamin-dependent methionine synthase and serine hydroxymethyltransferase: targets for chemotherapeutic intervention? 1998

R G Matthews, and J T Drummond, and H K Webb

Biophysics Research Division, University of Michigan, Ann Arbor 41809-1055, USA.

Chemotherapeutic drugs targeted at folate-dependent reactions have typically been directed at a limited number of target enzymes: dihydrofolate reductase, thymidylate synthase, and GAR and AICAR transformylase. This review discusses two other potential targets for chemotherapeutic inhibition: cobalamin-dependent methionine synthase and serine hydroxymethyltransferase. Brief reviews of the catalytic properties of these two enzymes are presented, and possible strategies for chemotherapeutic intervention are discussed.

UI	MeSH Term	Description	Entries
D007700	Kinetics	The rate dynamics in chemical or physical systems.
D004358	Drug Therapy	The use of DRUGS to treat a DISEASE or its symptoms. One example is the use of ANTINEOPLASTIC AGENTS to treat CANCER.	Chemotherapy,Pharmacotherapy,Therapy, Drug,Chemotherapies,Drug Therapies,Pharmacotherapies,Therapies, Drug
D004791	Enzyme Inhibitors	Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.	Enzyme Inhibitor,Inhibitor, Enzyme,Inhibitors, Enzyme
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000241	Adenosine	A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.	Adenocard,Adenoscan
D012696	Glycine Hydroxymethyltransferase	A pyridoxal phosphate enzyme that catalyzes the reaction of glycine and 5,10-methylene-tetrahydrofolate to form serine. It also catalyzes the reaction of glycine with acetaldehyde to form L-threonine. EC 2.1.2.1.	Serine Aldolase,Serine Hydroxymethylase,Serine Hydroxymethyltransferase,Serine Transhydroxymethylase,Threonine Aldolase,Allothreonine Aldolase,Aldolase, Allothreonine,Aldolase, Serine,Aldolase, Threonine,Hydroxymethylase, Serine,Hydroxymethyltransferase, Glycine,Hydroxymethyltransferase, Serine,Transhydroxymethylase, Serine
D013766	5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase	An enzyme that catalyzes the formation of methionine by transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine. It requires a cobamide coenzyme. The enzyme can act on mono- or triglutamate derivatives. EC 2.1.1.13.	Methionine Synthetase,Methyltetrahydrofolate Homocysteine Methyltransferase,Tetrahydropteroylglutamate Methyltransferase,Methionine Synthase,Vitamin B12-Dependent Methionine Synthase,Vitamin B12-Independent Methionine Synthase,Homocysteine Methyltransferase, Methyltetrahydrofolate,Methyltransferase, Methyltetrahydrofolate Homocysteine,Methyltransferase, Tetrahydropteroylglutamate,S-Methyltransferase, 5-Methyltetrahydrofolate-Homocysteine,Synthase, Methionine,Synthetase, Methionine
D013912	Threonine	An essential amino acid occurring naturally in the L-form, which is the active form. It is found in eggs, milk, gelatin, and other proteins.	L-Threonine,L Threonine
D014155	Transcobalamins	A group of carrier proteins which bind with VITAMIN B12 in the BLOOD and aid in its transport. Transcobalamin I migrates electrophoretically as a beta-globulin, while transcobalamins II and III migrate as alpha-globulins.	Cobalamin-Binding Protein,Transcobalamin,Transcobalamin II,Vitamin B 12-Binding Protein,Vitamin B 12-Binding Proteins,Vitamin B12-Binding Protein,Cobalamin-Binding Proteins,Cobalophilin,Haptocorrin,Holo-Transcobalamin II,R-Binder,Transcobalamin (I),Transcobalamin I,Transcobalamin III,Vitamin B 12 Binder,Vitamin B12-Binding Proteins,B12-Binding Protein, Vitamin,Cobalamin Binding Protein,Cobalamin Binding Proteins,Holo Transcobalamin II,Protein, Cobalamin-Binding,Protein, Vitamin B12-Binding,Proteins, Cobalamin-Binding,Proteins, Vitamin B12-Binding,R Binder,Vitamin B 12 Binding Protein,Vitamin B 12 Binding Proteins,Vitamin B12 Binding Protein,Vitamin B12 Binding Proteins
D015195	Drug Design	The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include PHARMACOKINETICS, dosage analysis, or drug administration analysis.	Computer-Aided Drug Design,Computerized Drug Design,Drug Modeling,Pharmaceutical Design,Computer Aided Drug Design,Computer-Aided Drug Designs,Computerized Drug Designs,Design, Pharmaceutical,Drug Design, Computer-Aided,Drug Design, Computerized,Drug Designs,Drug Modelings,Pharmaceutical Designs