Magnesium sulfate as an anticonvulsant in eclampsia. 1995

N V Raman, and C A Rao
Department of Obstetrics and Gynaecology, Institute of Obstetrics and Gynaecology, Ameenbagh, Hyderabad, India.

OBJECTIVE To examine the efficacy of magnesium sulfate (MgSO4) as an anticonvulsant in eclampsia and imminent eclampsia. METHODS Case records of 562 consecutive patients with eclampsia and 174 with imminent eclampsia treated at the Institute of Obstetrics and Gynaecology, Hyderabad, India, during the 3-year period from January 1987 to December 1989, were reviewed. Management consisted of: (1) MgSO4 to control convulsions; (2) sublingual nifedipine to control hypertension; and (3) delivery of the fetus. RESULTS Convulsions were controlled in 95% of cases with the initial dose of magnesium and within half an hour in a further 2%. Cesarean section was performed mainly for obstetric indications. Depression of knee jerks was found to be the first sign of impending magnesium toxicity and with the precautions observed, magnesium toxicity was negligible. Maternal mortality was 2.4% (18 maternal deaths) and perinatal mortality 36% (247 perinatal deaths). Sixteen women with eclampsia (2.8%) and two with imminent eclampsia (1.1%) died. Of the 247 perinatal deaths, 61 were in the category of imminent eclampsia. There were 10 sets of twins. Cerebrovascular accident was the leading cause of maternal death. Fetal deaths and prematurity were important causes of perinatal loss. CONCLUSIONS The control of convulsions is the most important aspect in the management of eclampsia, and MgSO4 is a very effective anticonvulsant.

UI MeSH Term Description Entries
D008278 Magnesium Sulfate A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083) Magnesium Sulfate, Heptahydrate,Heptahydrate Magnesium Sulfate,Sulfate, Magnesium
D009543 Nifedipine A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure. Adalat,BAY-a-1040,Bay-1040,Cordipin,Cordipine,Corinfar,Fenigidin,Korinfar,Nifangin,Nifedipine Monohydrochloride,Nifedipine-GTIS,Procardia,Procardia XL,Vascard,BAY a 1040,BAYa1040,Bay 1040,Bay1040,Monohydrochloride, Nifedipine,Nifedipine GTIS
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D011256 Pregnancy Outcome Results of conception and ensuing pregnancy, including LIVE BIRTH; STILLBIRTH; or SPONTANEOUS ABORTION. The outcome may follow natural or artificial insemination or any of the various ASSISTED REPRODUCTIVE TECHNIQUES, such as EMBRYO TRANSFER or FERTILIZATION IN VITRO. Outcome, Pregnancy,Outcomes, Pregnancy,Pregnancy Outcomes
D001724 Birth Weight The mass or quantity of heaviness of an individual at BIRTH. It is expressed by units of pounds or kilograms. Birthweight,Birth Weights,Birthweights,Weight, Birth,Weights, Birth
D004461 Eclampsia Onset of HYPERREFLEXIA; SEIZURES; or COMA in a previously diagnosed pre-eclamptic patient (PRE-ECLAMPSIA). Eclampsias
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

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