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Neuroleptic-induced Meige's syndrome following akathisia: pharmacologic characteristics. 1998

T Hayashi, and M Furutani, and J Taniyama, and M Kiyasu, and S Hikasa, and J Horiguchi, and S Yamawaki
Hiroshima Seiyoin Hospital, Department of Psychiatry and Neurosciences, Hiroshima University School of Medicine, Japan.

A 52-year-old schizophrenic patient acutely showed blepharospasm and oromandibular dystonia following neuroleptic-induced akathisia. She had suffered from schizophrenia and been treated with neuroleptics for 15 years and had manifested tardive dyskinesia 5 years ago. Following a change in her neuroleptic medication, severe akathisia developed. Two days after the appearance of akathisia, blepharospasm and oromandibular dystonia appeared. After the disappearance of akathisia, the disorder continued. The frequency of blepharospasm ranged from 30 to 40 (times/min). The oral administration of trihexyphenidyl (6 mg/day), perphenazine (12 mg/day), and fluphenazine (12 mg/day) significantly decreased the frequency of blepharospasm, whereas carbamazepine (600 mg/day) and sulpiride (1200 mg/day) did not. These results suggest that overactivity of both cholinergic and dopaminergic functions in the striatum may be involved in this patient. Our patient, who showed acute onset of Meige's syndrome following neuroleptic-induced akathisia, is of interest to those studying the pathogenesis of Meige's syndrome.

UI MeSH Term Description Entries
D008538 Meige Syndrome A syndrome characterized by orofacial DYSTONIA; including BLEPHAROSPASM; forceful jaw opening; lip retraction; platysma muscle spasm; and tongue protrusion. It primarily affects older adults, with an incidence peak in the seventh decade of life. (From Adams et al., Principles of Neurology, 6th ed, p108) Blepharospasm-Oromandibular Dystonia,Brueghel Syndrome,Idiopathic Orofacial Dyskinesia,Blepharospasm-Oromandibular Dyskinesia,Blepharospasm-Oromandibular Dystonia Syndrome,Blepharospasm-Oromandibular Dystonia Syndrome, Idiopathic,Idiopathic Blepharospasm-Oromandibular Dystonia Syndrome,Syndrome, Blepharospasm-Oromandibular Dystonia,Blepharospasm Oromandibular Dyskinesia,Blepharospasm Oromandibular Dystonia,Blepharospasm Oromandibular Dystonia Syndrome,Blepharospasm Oromandibular Dystonia Syndrome, Idiopathic,Blepharospasm-Oromandibular Dyskinesias,Blepharospasm-Oromandibular Dystonia Syndromes,Blepharospasm-Oromandibular Dystonias,Dyskinesia, Blepharospasm-Oromandibular,Dyskinesia, Idiopathic Orofacial,Dyskinesias, Blepharospasm-Oromandibular,Dyskinesias, Idiopathic Orofacial,Dystonia Syndrome, Blepharospasm-Oromandibular,Dystonia Syndromes, Blepharospasm-Oromandibular,Dystonia, Blepharospasm-Oromandibular,Dystonias, Blepharospasm-Oromandibular,Idiopathic Blepharospasm Oromandibular Dystonia Syndrome,Idiopathic Orofacial Dyskinesias,Orofacial Dyskinesia, Idiopathic,Orofacial Dyskinesias, Idiopathic
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011954 Receptors, Dopamine Cell-surface proteins that bind dopamine with high affinity and trigger intracellular changes influencing the behavior of cells. Dopamine Receptors,Dopamine Receptor,Receptor, Dopamine
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012559 Schizophrenia A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior. Dementia Praecox,Schizophrenic Disorders,Disorder, Schizophrenic,Disorders, Schizophrenic,Schizophrenias,Schizophrenic Disorder
D014150 Antipsychotic Agents Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. Antipsychotic,Antipsychotic Agent,Antipsychotic Drug,Antipsychotic Medication,Major Tranquilizer,Neuroleptic,Neuroleptic Agent,Neuroleptic Drug,Neuroleptics,Tranquilizing Agents, Major,Antipsychotic Drugs,Antipsychotic Effect,Antipsychotic Effects,Antipsychotics,Major Tranquilizers,Neuroleptic Agents,Neuroleptic Drugs,Tranquillizing Agents, Major,Agent, Antipsychotic,Agent, Neuroleptic,Drug, Antipsychotic,Drug, Neuroleptic,Effect, Antipsychotic,Major Tranquilizing Agents,Major Tranquillizing Agents,Medication, Antipsychotic,Tranquilizer, Major
D014793 Visual Cortex Area of the OCCIPITAL LOBE concerned with the processing of visual information relayed via VISUAL PATHWAYS. Area V2,Area V3,Area V4,Area V5,Associative Visual Cortex,Brodmann Area 18,Brodmann Area 19,Brodmann's Area 18,Brodmann's Area 19,Cortical Area V2,Cortical Area V3,Cortical Area V4,Cortical Area V5,Secondary Visual Cortex,Visual Cortex Secondary,Visual Cortex V2,Visual Cortex V3,Visual Cortex V3, V4, V5,Visual Cortex V4,Visual Cortex V5,Visual Cortex, Associative,Visual Motion Area,Extrastriate Cortex,Area 18, Brodmann,Area 18, Brodmann's,Area 19, Brodmann,Area 19, Brodmann's,Area V2, Cortical,Area V3, Cortical,Area V4, Cortical,Area V5, Cortical,Area, Visual Motion,Associative Visual Cortices,Brodmanns Area 18,Brodmanns Area 19,Cortex Secondary, Visual,Cortex V2, Visual,Cortex V3, Visual,Cortex, Associative Visual,Cortex, Extrastriate,Cortex, Secondary Visual,Cortex, Visual,Cortical Area V3s,Extrastriate Cortices,Secondary Visual Cortices,V3, Cortical Area,V3, Visual Cortex,V4, Area,V4, Cortical Area,V5, Area,V5, Cortical Area,V5, Visual Cortex,Visual Cortex Secondaries,Visual Cortex, Secondary,Visual Motion Areas
D017109 Akathisia, Drug-Induced A condition associated with the use of certain medications and characterized by an internal sense of motor restlessness often described as an inability to resist the urge to move. Pseudoakathisia,Acathisia, Drug-Induced,Akathisia, Tardive,Drug-Induced Akathisia,Acathisia, Drug Induced,Akathisia, Drug Induced,Drug Induced Akathisia,Drug-Induced Acathisia,Tardive Akathisia

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