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Quantification of penicillin-G and procaine in equine urine and plasma using high-performance liquid chromatography. 1998
Y Luo, and
B McNamara, and
M A Fennell, and
D C Teleis, and
L May, and
J Rudy, and
A O Watson, and
C E Uboh, and
L R Soma
University of Pennsylvania, School of Veterinary Medicine, New Bolton Center Campus, Philadelphia 19348, USA.
A rapid and sensitive method for the extraction and quantification of penicillin-G and procaine in horse urine and plasma samples has been successfully developed. The method involves the use of solid-phase extraction (SPE) for penicillin-G, liquid-liquid extraction (LLE) for procaine, and high-performance liquid chromatography (HPLC) for the quantification of penicillin-G and procaine. The new method described here has been successfully applied in the pharmacokinetic studies of procaine, penicillin-G and procaine-penicillin-G administrations in the horse.
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