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OBJECTIVE Evaluate the frequency and assess curative and preventive measures against urinary lithiasis in patients treated with indinavir. METHODS Fourteen HIV seropositive patients who developed severe and acute flank pain were included. Four of the patients receiving 800 mg indinavir t.i.d. had fever (38.5 degrees C) or delayed secretion (> 2 h). Delay from indinavir treatment onset was 1 to 321 days. During the same period, 155 patients had been treated with indinavir. Clinical features, radiology and laboratory results were recorded in addition to an analysis of the lithiasis if possible. RESULTS Transient moderate renal failure occurred in 8 patients. Mean urine pH was 6. Serum phosphorus, calcium, and uric acid, liver tests and urinalysis were normal. A JJ ureteral stent was inserted in 4 cases due to complications. In all cases, fluids, analgesics and antispasmodics provided favorable outcome. Inversely, nonsteroid antiinflammatory drugs given in 2 patients had a deleterious effect on renal function. The lithiasis was eliminated in 3 cases and infrared spectrophotometry demonstrated a structure compatible with indinavir monohydrate. CONCLUSIONS The formation of urinary lithiasis is a frequent complication of indinavir therapy (9%). Hyperhydration and urine acidification are usually successful but emergency drainage is required in approximately 3% of cases. Nonsteroidal antiinflammatory drugs should be avoided due to the risk of renal toxicity. A precise evaluation of fluid intake and diet, drug associations and personal history is needed to recognize patients at risk of recurrent lithiasis formation.
J F Hermieu, and
M H Prévot, and
V Ravery, and
F Moulinier, and
V Delmas, and
E Bouvet, and
L Boccon-Gibod
January 1997,
La Revue de medecine interne,
J F Hermieu, and
M H Prévot, and
V Ravery, and
F Moulinier, and
V Delmas, and
E Bouvet, and
L Boccon-Gibod
June 1957,
Concours medical,
J F Hermieu, and
M H Prévot, and
V Ravery, and
F Moulinier, and
V Delmas, and
E Bouvet, and
L Boccon-Gibod
July 1964,
Medicina clinica,
J F Hermieu, and
M H Prévot, and
V Ravery, and
F Moulinier, and
V Delmas, and
E Bouvet, and
L Boccon-Gibod
October 1877,
Atlanta medical and surgical journal,
J F Hermieu, and
M H Prévot, and
V Ravery, and
F Moulinier, and
V Delmas, and
E Bouvet, and
L Boccon-Gibod
January 1969,
La Tunisie medicale,
J F Hermieu, and
M H Prévot, and
V Ravery, and
F Moulinier, and
V Delmas, and
E Bouvet, and
L Boccon-Gibod
June 1963,
Montpellier medical,
J F Hermieu, and
M H Prévot, and
V Ravery, and
F Moulinier, and
V Delmas, and
E Bouvet, and
L Boccon-Gibod
October 1980,
Acta urologica Belgica,
J F Hermieu, and
M H Prévot, and
V Ravery, and
F Moulinier, and
V Delmas, and
E Bouvet, and
L Boccon-Gibod
March 1972,
Bordeaux medical,
J F Hermieu, and
M H Prévot, and
V Ravery, and
F Moulinier, and
V Delmas, and
E Bouvet, and
L Boccon-Gibod
September 1960,
La Presse medicale,
J F Hermieu, and
M H Prévot, and
V Ravery, and
F Moulinier, and
V Delmas, and
E Bouvet, and
L Boccon-Gibod
November 1880,
Buffalo medical and surgical journal,
