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The effect of acarbose, an alpha-glucosidase inhibitor, on postprandial glucose and lipid metabolism was investigated in patients with type 2 diabetes mellitus. Twenty patients (10 men and 10 women) with type 2 diabetes mellitus were studied. A test meal was taken with or without 100 mg of acarbose. The levels of plasma glucose, and serum immunoreactive insulin, lipids, apolipoproteins, and remnant-like particle cholesterol were investigated. Acarbose inhibited the postprandial increase of both plasma glucose and serum immunoreactive insulin. Acarbose also significantly suppressed the increase of serum triglycerides at 60, 90, and 120 min (P < 0.05 to P < 0.01), and the increase of serum remnant-like particle cholesterol at 60 and 120 min (P < 0.05). Acarbose inhibited the postprandial decline of apolipoprotein C-II, and decreased the postprandial serum apolipoprotein C-III level. These results suggest that acarbose may improve postprandial hyperlipidemia as well as postprandial hyperglycemia in patients with type 2 diabetes mellitus.
S Kado, and
T Murakami, and
A Aoki, and
T Nagase, and
Y Katsura, and
M Noritake, and
T Matsuoka, and
N Nagata
April 2022,
European journal of endocrinology,
S Kado, and
T Murakami, and
A Aoki, and
T Nagase, and
Y Katsura, and
M Noritake, and
T Matsuoka, and
N Nagata
December 2005,
The Journal of the Association of Physicians of India,
S Kado, and
T Murakami, and
A Aoki, and
T Nagase, and
Y Katsura, and
M Noritake, and
T Matsuoka, and
N Nagata
July 2015,
Journal of the American Geriatrics Society,
S Kado, and
T Murakami, and
A Aoki, and
T Nagase, and
Y Katsura, and
M Noritake, and
T Matsuoka, and
N Nagata
June 2009,
Advances in therapy,
S Kado, and
T Murakami, and
A Aoki, and
T Nagase, and
Y Katsura, and
M Noritake, and
T Matsuoka, and
N Nagata
March 2021,
Journal of family medicine and primary care,
S Kado, and
T Murakami, and
A Aoki, and
T Nagase, and
Y Katsura, and
M Noritake, and
T Matsuoka, and
N Nagata
September 2002,
The Journal of family practice,
S Kado, and
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A Aoki, and
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Y Katsura, and
M Noritake, and
T Matsuoka, and
N Nagata
December 2020,
Artificial cells, nanomedicine, and biotechnology,
S Kado, and
T Murakami, and
A Aoki, and
T Nagase, and
Y Katsura, and
M Noritake, and
T Matsuoka, and
N Nagata
January 1985,
Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten,
S Kado, and
T Murakami, and
A Aoki, and
T Nagase, and
Y Katsura, and
M Noritake, and
T Matsuoka, and
N Nagata
December 2004,
Clinical autonomic research : official journal of the Clinical Autonomic Research Society,
S Kado, and
T Murakami, and
A Aoki, and
T Nagase, and
Y Katsura, and
M Noritake, and
T Matsuoka, and
N Nagata
January 2010,
Diabetes technology & therapeutics,
