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OBJECTIVE To investigate clinical efficacy of angiotensin-converting enzyme inhibitor trandolapril and its effects on myocardial function. METHODS 20 patients with ischemic heart disease (IHD) aged 33-74 years with chronic cardiac failure NYHA class II-IV. 4 of them survived myocardial infarction. In addition to the routine tests, the patients underwent echocardiography, radionuclide ventriculography. Trandolapril was given once a day for 28 days in a dose 2 mg, then a repeat examination was performed. RESULTS Trandolapril produced a subjective effect in 80% of patients. There was also improvement of hemodynamic parameters, an increase in the ejection fraction, sensitivity to nitroglycerin, decline of asynchrony. The drug was well tolerated. CONCLUSIONS Trandolapril (Gopten) is effective in IHD patients with chronic cardiac failure.
I M Kakhnovskiĭ, and
I G Fomina, and
E L Ostroumov, and
V M Lepeshkov, and
N E Gaĭdamakina, and
O V Kaveshnikova, and
Z S Markova, and
E L Lugovaia
January 2004,
Kardiologiia,
I M Kakhnovskiĭ, and
I G Fomina, and
E L Ostroumov, and
V M Lepeshkov, and
N E Gaĭdamakina, and
O V Kaveshnikova, and
Z S Markova, and
E L Lugovaia
June 1998,
Likars'ka sprava,
I M Kakhnovskiĭ, and
I G Fomina, and
E L Ostroumov, and
V M Lepeshkov, and
N E Gaĭdamakina, and
O V Kaveshnikova, and
Z S Markova, and
E L Lugovaia
January 1998,
Terapevticheskii arkhiv,
I M Kakhnovskiĭ, and
I G Fomina, and
E L Ostroumov, and
V M Lepeshkov, and
N E Gaĭdamakina, and
O V Kaveshnikova, and
Z S Markova, and
E L Lugovaia
September 2003,
Polskie Archiwum Medycyny Wewnetrznej,
I M Kakhnovskiĭ, and
I G Fomina, and
E L Ostroumov, and
V M Lepeshkov, and
N E Gaĭdamakina, and
O V Kaveshnikova, and
Z S Markova, and
E L Lugovaia
September 1998,
Cardiovascular drugs and therapy,
I M Kakhnovskiĭ, and
I G Fomina, and
E L Ostroumov, and
V M Lepeshkov, and
N E Gaĭdamakina, and
O V Kaveshnikova, and
Z S Markova, and
E L Lugovaia
September 1989,
Vrachebnoe delo,
I M Kakhnovskiĭ, and
I G Fomina, and
E L Ostroumov, and
V M Lepeshkov, and
N E Gaĭdamakina, and
O V Kaveshnikova, and
Z S Markova, and
E L Lugovaia
September 1989,
Vrachebnoe delo,
I M Kakhnovskiĭ, and
I G Fomina, and
E L Ostroumov, and
V M Lepeshkov, and
N E Gaĭdamakina, and
O V Kaveshnikova, and
Z S Markova, and
E L Lugovaia
January 2002,
Kardiologiia,
I M Kakhnovskiĭ, and
I G Fomina, and
E L Ostroumov, and
V M Lepeshkov, and
N E Gaĭdamakina, and
O V Kaveshnikova, and
Z S Markova, and
E L Lugovaia
August 1986,
Vrachebnoe delo,
I M Kakhnovskiĭ, and
I G Fomina, and
E L Ostroumov, and
V M Lepeshkov, and
N E Gaĭdamakina, and
O V Kaveshnikova, and
Z S Markova, and
E L Lugovaia
July 1984,
Vrachebnoe delo,
