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In this review, various aspects of gastrointestinal microcirculation were described. Endothelin-1, vasoconstrictor, is elevated in gastric mucosa, causes gastric ischemia and results in gastric ulceration in human and animals under physical stress. Vasodilators such as NO anticipate the alove actions of endothelin, and thereby protect mucosa from injury. Once ulcer is developed, angiogenesis plays a key role in its healing. Various growth factors, cyclooxygenases-1 and -2, and non-peptide angiogenic factors stimulate this phenomenon and participate in ulcer healing. However, acidic conditions, H. pylori and its product, ammonia, suppress angiogenesis in vitro and in vivo. These evidences may explain why ulcer heals so slowly in gastroduodenal mucosa.
S Tsuji, and
S Kawano, and
M Tsujii, and
T Michida, and
E Masuda, and
E S Gunawan, and
M Hori
August 2003,
Critical care medicine,
S Tsuji, and
S Kawano, and
M Tsujii, and
T Michida, and
E Masuda, and
E S Gunawan, and
M Hori
October 1993,
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery,
S Tsuji, and
S Kawano, and
M Tsujii, and
T Michida, and
E Masuda, and
E S Gunawan, and
M Hori
January 1979,
Major problems in pathology,
S Tsuji, and
S Kawano, and
M Tsujii, and
T Michida, and
E Masuda, and
E S Gunawan, and
M Hori
January 1973,
Major problems in pathology,
S Tsuji, and
S Kawano, and
M Tsujii, and
T Michida, and
E Masuda, and
E S Gunawan, and
M Hori
October 2010,
Periodontology 2000,
S Tsuji, and
S Kawano, and
M Tsujii, and
T Michida, and
E Masuda, and
E S Gunawan, and
M Hori
April 2008,
World journal of gastroenterology,
S Tsuji, and
S Kawano, and
M Tsujii, and
T Michida, and
E Masuda, and
E S Gunawan, and
M Hori
January 2011,
Cell and tissue research,
S Tsuji, and
S Kawano, and
M Tsujii, and
T Michida, and
E Masuda, and
E S Gunawan, and
M Hori
November 2001,
International journal of hematology,
S Tsuji, and
S Kawano, and
M Tsujii, and
T Michida, and
E Masuda, and
E S Gunawan, and
M Hori
February 2017,
Ugeskrift for laeger,
S Tsuji, and
S Kawano, and
M Tsujii, and
T Michida, and
E Masuda, and
E S Gunawan, and
M Hori
December 2012,
Immunologic research,
