Biomaterial Database

Bioavailability of 11 sulfisoxazole products in humans. 1976

G W Slywka, and A P Melikian, and A B Straughn, and P L Whyatt, and M C Meyer

Single lots of 11 commercially available 500-mg sulfisoxazole tablets were evaluated in vitro and in vivo. All products tested met USP XVIII specifications for weight variation and product assay. However, three products failed to meet the USP XVIII dissolution requirement. The only statistically significant difference observed between the 11 products was a lower peak plasma level exhibited by one product. No useful correlation was observed between the in vivo and in vitro studies for the dosage forms tested.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D001682	Biological Availability	The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.	Availability Equivalency,Bioavailability,Physiologic Availability,Availability, Biologic,Availability, Biological,Availability, Physiologic,Biologic Availability,Availabilities, Biologic,Availabilities, Biological,Availabilities, Physiologic,Availability Equivalencies,Bioavailabilities,Biologic Availabilities,Biological Availabilities,Equivalencies, Availability,Equivalency, Availability,Physiologic Availabilities
D012995	Solubility	The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Solubilities
D013444	Sulfisoxazole	A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms.	Sulfafurazole,Gantrisin,Gantrisin Pediatric,Neoxazoi,Sulfadimethyloxazole,Sulfafurazol FNA,Sulfasoxizole,Sulfisoxazole Diolamine,Sulfisoxazole, Ammonium Salt,Sulfisoxazole, Monolithium Salt,Sulfisoxazole, Monosodium Salt,Sulfisoxazole, Monosodium, Monomesylate Salt,Sulfisoxazole, Triammonium Salt,TL-azole,V-Sul,Ammonium Salt Sulfisoxazole,Diolamine, Sulfisoxazole,Monolithium Salt Sulfisoxazole,Monosodium Salt Sulfisoxazole,Pediatric, Gantrisin,TL azole,Triammonium Salt Sulfisoxazole,V Sul
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor