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The preoperative levels of serum-soluble receptor for interleukin-2 (IL-2R) were determined by an enzyme-linked immunosorbent assay in 38 patients undergoing surgery for colorectal cancer and 98 healthy controls. The levels of serum-soluble IL-2R in the patients with colorectal cancer were significantly higher than those in the normal controls (P < 0.05). Markedly elevated levels of serum-soluble IL-2R were recognized in patients with stage IV cancer, those with Dukes' stage D cancer, and those with liver metastasis. Moreover, the prognosis of patients with low levels of IL-2R (<531 U/ml) was significantly better than that of those with high levels (P < 0.05). These findings demonstrate that an elevated concentration of soluble IL-2R might be a useful indicator of liver metastasis and poor prognosis in patients with colorectal carcinoma.
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March 1997,
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H Saito, and
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H Saito, and
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Clinical and experimental immunology,
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H Saito, and
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April 1998,
Anales de medicina interna (Madrid, Spain : 1984),
H Saito, and
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August 1993,
Arerugi = [Allergy],
H Saito, and
S Tsujitani, and
K Katano, and
M Ikeguchi, and
M Maeta, and
N Kaibara
March 1994,
Gynecologic oncology,
H Saito, and
S Tsujitani, and
K Katano, and
M Ikeguchi, and
M Maeta, and
N Kaibara
January 1996,
Hepato-gastroenterology,
H Saito, and
S Tsujitani, and
K Katano, and
M Ikeguchi, and
M Maeta, and
N Kaibara
June 1998,
Yan ke xue bao = Eye science,
H Saito, and
S Tsujitani, and
K Katano, and
M Ikeguchi, and
M Maeta, and
N Kaibara
November 1994,
Cancer,
