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BACKGROUND The dopaminergic receptor genes are candidate genes for manic-depressive illness (MDI). To test this putative involvement we used a case-control study on samples from the native population of the northwest part of France. METHODS Fifty patients for D1 and D2, 61 patients for D3, and 86-223 controls were tested. RESULTS No significant association was found between allelic frequencies or genotype counts and MDI, even when the data were pooled with those from published studies. CONCLUSIONS Single mutations of either of the studied receptor genes are not major determinants of MDI.
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