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The enzyme aromatase is involved in the conversion of androgens to estrogens and in the modulation of various androgenic and estrogenic actions. Abnormalities of estrogen metabolism have been postulated to play roles in the development and/or pathophysiology of Sjögren's syndrome. In the present study, aromatase was immunolocalized in 75 cases of inflammatory disorders of human minor salivary glands of the lower lip. These included cases of primary Sjögren's syndrome (19 cases), of chronic sialadenitis (34 cases) and of mucous extravasation cysts (22 cases), in order to clarify the possible involvement of in situ estrogen production in primary Sjögren's syndrome. Aromatase immunoreactivity was detected in myoepithelial cells of acini and in interstitial cells adjacent to acini and ducts in 13/19 (68%) cases of primary Sjögren's syndrome. In contrast, aromatase expression was detected in only six of 34 (18%) cases of chronic sialadenitis and in seven of 22 (32%) cases of mucous extravasation cyst. These results suggest that increased aromatase expression in minor salivary glands with primary Sjögren's syndrome in premenopausal women may be involved in the biological features of primary Sjögren's syndrome through the production of estrogens in situ and possibly through the aggravation of the inflammatory reaction.
K Onodera, and
H Sasano, and
R Ichinohasama, and
K Ooya
January 1981,
Stomatologiia,
K Onodera, and
H Sasano, and
R Ichinohasama, and
K Ooya
January 2010,
Reumatologia clinica,
K Onodera, and
H Sasano, and
R Ichinohasama, and
K Ooya
March 1985,
Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology,
K Onodera, and
H Sasano, and
R Ichinohasama, and
K Ooya
January 1998,
Autoimmunity,
K Onodera, and
H Sasano, and
R Ichinohasama, and
K Ooya
December 1990,
La Clinica terapeutica,
K Onodera, and
H Sasano, and
R Ichinohasama, and
K Ooya
August 2013,
Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology,
K Onodera, and
H Sasano, and
R Ichinohasama, and
K Ooya
May 2015,
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society,
K Onodera, and
H Sasano, and
R Ichinohasama, and
K Ooya
June 2017,
Autoimmunity,
K Onodera, and
H Sasano, and
R Ichinohasama, and
K Ooya
January 2020,
Frontiers in immunology,
K Onodera, and
H Sasano, and
R Ichinohasama, and
K Ooya
December 1995,
Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology,
