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Lack of R117H mutation in the cationic trypsinogen gene in patients with tropical pancreatitis from Bangladesh. 1998
L Rossi, and
D C Whitcomb, and
G D Ehrlich, and
M C Gorry, and
S Parvin, and
S Sattar, and
L Ali, and
A K Azad Khan, and
N Gyr
Research Division, Bangladesh Institute of Research & Rehabilitation in Diabetes, Endocrine & Metabolic Disorders, Dhaka.
The etiology of nonalcoholic chronic pancreatitis, occurring in tropical regions, is unknown. Although environmental factors may play a role in its pathogenesis, a specific genetic predisposition may be necessary. The genetic mutation responsible for hereditary pancreatitis was described recently. Unlike in patients with hereditary pancreatitis, we found a lack of the R117H mutation in the cationic trypsinogen gene in all patients with tropical pancreatitis from Bangladesh.
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