-transparent.png){kind=logo}
New phosphoramide mustards (6-8) have been prepared from the antibiotics 2 and 3, and from 5. The mixture of cyclophosphamides could be separated by preparative layer and column chromatography. The assignments of configuration to the isomeric phosphoramidates was based on the magnetic anisotropy of the P = O bond. The synthesized compounds 6a,b-8a,b (mixture of isomers) were tested for inhibitory activity on the [3H]-thymidine incorporation into the DNA of tumor cells, using ovarian carcinoma cell line.
Related Publications
A Csorvási, and
K E Kövér, and
M M Menyhárt, and
F Sztaricskai, and
Y V Dobrynin, and
T G Nikolaeva
August 2001,
Acta pharmaceutica Hungarica,
A Csorvási, and
K E Kövér, and
M M Menyhárt, and
F Sztaricskai, and
Y V Dobrynin, and
T G Nikolaeva
November 1980,
Journal of medicinal chemistry,
A Csorvási, and
K E Kövér, and
M M Menyhárt, and
F Sztaricskai, and
Y V Dobrynin, and
T G Nikolaeva
March 1976,
Cancer research,
A Csorvási, and
K E Kövér, and
M M Menyhárt, and
F Sztaricskai, and
Y V Dobrynin, and
T G Nikolaeva
June 1995,
Journal of medicinal chemistry,
A Csorvási, and
K E Kövér, and
M M Menyhárt, and
F Sztaricskai, and
Y V Dobrynin, and
T G Nikolaeva
January 2017,
Reproductive toxicology (Elmsford, N.Y.),
A Csorvási, and
K E Kövér, and
M M Menyhárt, and
F Sztaricskai, and
Y V Dobrynin, and
T G Nikolaeva
November 1993,
Journal of medicinal chemistry,
A Csorvási, and
K E Kövér, and
M M Menyhárt, and
F Sztaricskai, and
Y V Dobrynin, and
T G Nikolaeva
January 1982,
The Journal of antibiotics,
A Csorvási, and
K E Kövér, and
M M Menyhárt, and
F Sztaricskai, and
Y V Dobrynin, and
T G Nikolaeva
December 2017,
ACS medicinal chemistry letters,
A Csorvási, and
K E Kövér, and
M M Menyhárt, and
F Sztaricskai, and
Y V Dobrynin, and
T G Nikolaeva
November 1980,
Cancer research,
A Csorvási, and
K E Kövér, and
M M Menyhárt, and
F Sztaricskai, and
Y V Dobrynin, and
T G Nikolaeva
September 1981,
The Journal of antibiotics,
