Relationship between microalbuminuria, left ventricular mass and function in essential hypertension. 1998

S G Wu, and F R Jung, and S Y Wei, and C Z Su
Department of Internal Medicine, Municipal General Hospital for Women and Children, Kaohsiung, Taiwan, Republic of China.

To investigate the relationship of microalbuminuria, left ventricular hypertrophy and hypertension, 150 hypertensive patients were studied. All patients received a series of blood pressure (BP) measurements, overnight urine collection for microalbuminuria determination, chest radiography (CXR), electrocardiography (EKG) and echocardiographic assessment. Echocardiographic variables including left ventricular mass index (LVMI), fractional shortening (FS) and Doppler mitral flow E/A ratio were analyzed. Patients were divided into 4 groups according to diastolic blood pressure. Left ventricular hypertrophy (LVH) was identified by EKG in 28 patients (18.7%), by CXR in 56 patients (37.3%) and by echocardiography in 126 patients (89.3%). Microalbuminuria was detected in 42 patients (28%). Microalbuminuria tended to present in patients with higher systolic, diastolic and mean blood pressure. There was no relation between FS and E/A ratio and the degree of blood pressure elevation. However, there was a strong correlation between microalbuminuria and LVMI (p < 0.001), this correlation was not related to any difference in blood biochemistry. The results of this study indicate that the severity of microalbuminuria relates closely to the severity of hypertension. In addition, hypertensive patients with microalbuminuria tend to have higher LVMI.

UI MeSH Term Description Entries
D006973 Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. Blood Pressure, High,Blood Pressures, High,High Blood Pressure,High Blood Pressures
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D000369 Aged, 80 and over Persons 80 years of age and older. Oldest Old
D000419 Albuminuria The presence of albumin in the urine, an indicator of KIDNEY DISEASES. Albuminurias
D016277 Ventricular Function, Left The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance. Left Ventricular Function,Function, Left Ventricular,Functions, Left Ventricular,Left Ventricular Functions,Ventricular Functions, Left

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