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Antithymocyte globulin (ATG) is an effective immunosuppressive therapy for aplastic anemia (AA). We administered ATG combined with cyclosporine (CyA), to 9 patients (4 men and 5 women; median age, 55 years). AA was severe in 8 patients and moderate in 1. The ATG and CyA regimen was the initial treatment for 3 patients, but sequential treatment for the other 6, who were refractory to other agents. Peripheral T lymphocytes, including CD4-positive and CD8-positive cells, decreased rapidly after treatment. Although 1 patient died of pulmonary hemorrhage during the 6-month period following treatment with this combined regimen, 3 showed a favorable response, 2 moderate response, and 3 no response at all. Adverse drug reactions, including transient fever and rash, were not severe. These findings suggested that ATG and CyA in combination are a safe and effective immunosuppressive regimen for initial and refractory patients with AA.
S Ohnishi, and
M Nakagawa, and
N Kobayashi, and
M Ogasawara, and
Y Kiyama, and
T Naohara, and
T Higa, and
M Kasai
April 1982,
Scandinavian journal of haematology,
S Ohnishi, and
M Nakagawa, and
N Kobayashi, and
M Ogasawara, and
Y Kiyama, and
T Naohara, and
T Higa, and
M Kasai
July 2023,
Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion,
S Ohnishi, and
M Nakagawa, and
N Kobayashi, and
M Ogasawara, and
Y Kiyama, and
T Naohara, and
T Higa, and
M Kasai
May 2014,
Annals of hematology,
S Ohnishi, and
M Nakagawa, and
N Kobayashi, and
M Ogasawara, and
Y Kiyama, and
T Naohara, and
T Higa, and
M Kasai
January 1986,
Sangre,
S Ohnishi, and
M Nakagawa, and
N Kobayashi, and
M Ogasawara, and
Y Kiyama, and
T Naohara, and
T Higa, and
M Kasai
November 2004,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
S Ohnishi, and
M Nakagawa, and
N Kobayashi, and
M Ogasawara, and
Y Kiyama, and
T Naohara, and
T Higa, and
M Kasai
August 2019,
Annals of transplantation,
S Ohnishi, and
M Nakagawa, and
N Kobayashi, and
M Ogasawara, and
Y Kiyama, and
T Naohara, and
T Higa, and
M Kasai
December 1982,
Transplantation proceedings,
S Ohnishi, and
M Nakagawa, and
N Kobayashi, and
M Ogasawara, and
Y Kiyama, and
T Naohara, and
T Higa, and
M Kasai
April 2013,
Zhongguo shi yan xue ye xue za zhi,
S Ohnishi, and
M Nakagawa, and
N Kobayashi, and
M Ogasawara, and
Y Kiyama, and
T Naohara, and
T Higa, and
M Kasai
July 2010,
Haematologica,
S Ohnishi, and
M Nakagawa, and
N Kobayashi, and
M Ogasawara, and
Y Kiyama, and
T Naohara, and
T Higa, and
M Kasai
January 1985,
Acta haematologica,
