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We describe an alloimmunized female patient who developed serious adverse reactions when receiving HPA-incompatible platelet transfusions. She had received 13 transfusions with random platelets before the first allergic reactions. Antibodies against both the human leucocyte antigens (HLA) and several human platelet antigens (HPA) were detected at the time of transfusions. When the patient received HLA- and HPA-compatible platelets, no reactions followed the transfusions and platelet count increments were good. When she was transfused with platelets from donors with one foreign HLA antigen, her reactions were fever, chills and headache and the response to platelet transfusions was poor. When the platelets were HLA compatible but HPA incompatible, the reactions were repeatedly rapid pulse, shortness of breath, tightness of chest and wheezing interpretable as anaphylactoid reactions. Platelet count increments were satisfactory. When rare side-effects occur after transfusion, detailed immunohaematological studies are indicated.
M K Sirén, and
A Koponen, and
R Kekomäki
January 1996,
Vox sanguinis,
M K Sirén, and
A Koponen, and
R Kekomäki
August 1991,
Zhonghua yi xue za zhi = Chinese medical journal; Free China ed,
M K Sirén, and
A Koponen, and
R Kekomäki
February 1998,
European journal of haematology,
M K Sirén, and
A Koponen, and
R Kekomäki
August 1997,
Blood,
M K Sirén, and
A Koponen, and
R Kekomäki
January 1986,
Current studies in hematology and blood transfusion,
M K Sirén, and
A Koponen, and
R Kekomäki
April 1990,
Lancet (London, England),
M K Sirén, and
A Koponen, and
R Kekomäki
January 2020,
Internal medicine (Tokyo, Japan),
M K Sirén, and
A Koponen, and
R Kekomäki
November 1987,
British journal of haematology,
M K Sirén, and
A Koponen, and
R Kekomäki
January 1992,
Beitrage zur Infusionstherapie = Contributions to infusion therapy,
M K Sirén, and
A Koponen, and
R Kekomäki
March 1987,
British journal of haematology,
