-transparent.png){kind=logo}
BACKGROUND Parkinson's disease is thought to be secondary to the presence of neurotoxins, and pesticides have been implicated as possible causative agents. Glutathione transferases (GST) metabolise xenobiotics, including pesticides. Therefore, we investigated the role of GST polymorphisms in the pathogenesis of idiopathic Parkinson's disease. METHODS We genotyped by PCR polymorphisms in four GST classes (GSTM1, GSTT1, GSTP1, and GSTZ1) in 95 Parkinson's disease patients and 95 controls. We asked all patients for information about pesticide exposure. RESULTS The distribution of the GSTP1 genotypes differed significantly between patients and controls who had been exposed to pesticides (controls vs patients: AA 14 [54%] of 26 vs seven [18%] of 39; AB 11 [42%] of 26 vs 22 [56%] of 39; BB 1 [4%] of 26 vs six [15%] of 39; AC 0 vs four [10%] of 39, p=0.009). No association was found with any of the other GST polymorphisms. Pesticide exposure and a positive family history were risk factors for Parkinson's disease. CONCLUSIONS GSTP1-1, which is expressed in the blood-brain barrier, may influence response to neurotoxins and explain the susceptibility of some people to the parkinsonism-inducing effects of pesticides.
A Menegon, and
P G Board, and
A C Blackburn, and
G D Mellick, and
D G Le Couteur
March 2001,
Journal of neurology, neurosurgery, and psychiatry,
A Menegon, and
P G Board, and
A C Blackburn, and
G D Mellick, and
D G Le Couteur
January 2003,
Neuroscience letters,
A Menegon, and
P G Board, and
A C Blackburn, and
G D Mellick, and
D G Le Couteur
March 2014,
Journal of the neurological sciences,
A Menegon, and
P G Board, and
A C Blackburn, and
G D Mellick, and
D G Le Couteur
February 2016,
Neurological research,
A Menegon, and
P G Board, and
A C Blackburn, and
G D Mellick, and
D G Le Couteur
January 1999,
Lancet (London, England),
A Menegon, and
P G Board, and
A C Blackburn, and
G D Mellick, and
D G Le Couteur
March 2007,
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics,
A Menegon, and
P G Board, and
A C Blackburn, and
G D Mellick, and
D G Le Couteur
January 2000,
Journal of neural transmission (Vienna, Austria : 1996),
A Menegon, and
P G Board, and
A C Blackburn, and
G D Mellick, and
D G Le Couteur
June 2012,
Parkinsonism & related disorders,
A Menegon, and
P G Board, and
A C Blackburn, and
G D Mellick, and
D G Le Couteur
July 2005,
Movement disorders : official journal of the Movement Disorder Society,
A Menegon, and
P G Board, and
A C Blackburn, and
G D Mellick, and
D G Le Couteur
May 2004,
Neurology,
