BIOMAT Database Logo BIOMAT Database Logo

Effect of xenon-induced flow activation on xenon-enhanced computed tomography cerebral blood flow calculations. 1998

W D Obrist, and Z Zhang, and H Yonas
Department of Neurosurgery, University of Pittsburgh, Pennsylvania, USA.

Computer simulations of stable xenon ((S)Xe) uptake curves were used to evaluate the effect of xenon-induced flow activation on CBF calculations by xenon-enhanced computed tomography. Estimates of flow activation were based on repeated transcranial Doppler measurements of blood velocity during 4.5 minutes of (S)Xe inhalation. The synthetic curves were generated from a generalized Kety equation that included time-varying blood flow activation. In contrast to the peak 35% increase in blood flow velocity during (S)Xe inhalation, a standard analysis of the flow-varying synthetic curves revealed only minor 3% to 5% increases in calculated CBF. It is concluded that brief xenon inhalations can provide blood flow estimates that contain minimal bias from activation.

UI MeSH Term Description Entries
D008955 Models, Cardiovascular Theoretical representations that simulate the behavior or activity of the cardiovascular system, processes, or phenomena; includes the use of mathematical equations, computers and other electronic equipment. Cardiovascular Model,Cardiovascular Models,Model, Cardiovascular
D001783 Blood Flow Velocity A value equal to the total volume flow divided by the cross-sectional area of the vascular bed. Blood Flow Velocities,Flow Velocities, Blood,Flow Velocity, Blood,Velocities, Blood Flow,Velocity, Blood Flow
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D002536 Cerebral Arteries The arterial blood vessels supplying the CEREBRUM. Arteries, Cerebral,Artery, Cerebral,Cerebral Artery
D002560 Cerebrovascular Circulation The circulation of blood through the BLOOD VESSELS of the BRAIN. Brain Blood Flow,Regional Cerebral Blood Flow,Cerebral Blood Flow,Cerebral Circulation,Cerebral Perfusion Pressure,Circulation, Cerebrovascular,Blood Flow, Brain,Blood Flow, Cerebral,Brain Blood Flows,Cerebral Blood Flows,Cerebral Circulations,Cerebral Perfusion Pressures,Circulation, Cerebral,Flow, Brain Blood,Flow, Cerebral Blood,Perfusion Pressure, Cerebral,Pressure, Cerebral Perfusion
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000280 Administration, Inhalation The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract. Drug Administration, Inhalation,Drug Administration, Respiratory,Drug Aerosol Therapy,Inhalation Drug Administration,Inhalation of Drugs,Respiratory Drug Administration,Aerosol Drug Therapy,Aerosol Therapy, Drug,Drug Therapy, Aerosol,Inhalation Administration,Administration, Inhalation Drug,Administration, Respiratory Drug,Therapy, Aerosol Drug,Therapy, Drug Aerosol
D014055 Tomography, Emission-Computed Tomography using radioactive emissions from injected RADIONUCLIDES and computer ALGORITHMS to reconstruct an image. CAT Scan, Radionuclide,CT Scan, Radionuclide,Computerized Emission Tomography,Radionuclide Tomography, Computed,Scintigraphy, Computed Tomographic,Tomography, Radionuclide-Computed,Computed Tomographic Scintigraphy,Emission-Computed Tomography,Radionuclide Computer-Assisted Tomography,Radionuclide Computerized Tomography,Radionuclide-Computed Tomography,Radionuclide-Emission Computed Tomography,Tomography, Computerized Emission,CAT Scans, Radionuclide,CT Scans, Radionuclide,Computed Radionuclide Tomography,Computed Tomography, Radionuclide-Emission,Computer-Assisted Tomographies, Radionuclide,Computer-Assisted Tomography, Radionuclide,Computerized Tomography, Radionuclide,Emission Computed Tomography,Emission Tomography, Computerized,Radionuclide CAT Scan,Radionuclide CAT Scans,Radionuclide CT Scan,Radionuclide CT Scans,Radionuclide Computed Tomography,Radionuclide Computer Assisted Tomography,Radionuclide Computer-Assisted Tomographies,Radionuclide Emission Computed Tomography,Scan, Radionuclide CAT,Scan, Radionuclide CT,Scans, Radionuclide CAT,Scans, Radionuclide CT,Tomographic Scintigraphy, Computed,Tomographies, Radionuclide Computer-Assisted,Tomography, Computed Radionuclide,Tomography, Emission Computed,Tomography, Radionuclide Computed,Tomography, Radionuclide Computer-Assisted,Tomography, Radionuclide Computerized,Tomography, Radionuclide-Emission Computed
D014980 Xenon Radioisotopes Unstable isotopes of xenon that decay or disintegrate emitting radiation. Xe atoms with atomic weights 121-123, 125, 127, 133, 135, 137-145 are radioactive xenon isotopes. Radioisotopes, Xenon
D017585 Ultrasonography, Doppler, Transcranial A non-invasive technique using ultrasound for the measurement of cerebrovascular hemodynamics, particularly cerebral blood flow velocity and cerebral collateral flow. With a high-intensity, low-frequency pulse probe, the intracranial arteries may be studied transtemporally, transorbitally, or from below the foramen magnum. Doppler Sonography, Transcranial,Doppler Transcranial Sonography,Doppler Transcranial Ultrasonography,Doppler Ultrasonography, Transcranial,Sonography, Transcranial Doppler,Ultrasonography, Transcranial Doppler,Neurosonology,Sonography, Doppler Transcranial,Transcranial Doppler Sonography,Transcranial Doppler Ultrasonography,Transcranial Sonography, Doppler,Transcranial Ultrasonography, Doppler,Ultrasonography, Doppler Transcranial,Neurosonologies

Related Publications

W D Obrist, and Z Zhang, and H Yonas
The xenon-enhanced computed tomography cerebral blood flow method.
December 1998, Neurosurgery,
W D Obrist, and Z Zhang, and H Yonas
Xenon enhanced dynamic computed tomography: multilevel cerebral blood flow studies.
June 1981, Journal of computer assisted tomography,
W D Obrist, and Z Zhang, and H Yonas
The effect of computed tomography noise and tissue heterogeneity on cerebral blood flow determination by xenon-enhanced computed tomography.
January 1987, Medical physics,
W D Obrist, and Z Zhang, and H Yonas
Mapping cerebral blood flow by xenon-enhanced computed tomography: clinical experience.
August 1984, Radiology,
W D Obrist, and Z Zhang, and H Yonas
Regional cerebral blood flow in schizophrenia using stable xenon-enhanced computed tomography.
January 1999, Neuropsychobiology,
W D Obrist, and Z Zhang, and H Yonas
In vivo mapping of local cerebral blood flow by xenon-enhanced computed tomography.
March 1982, Science (New York, N.Y.),
W D Obrist, and Z Zhang, and H Yonas
[Measurement of cerebral blood flow by stable xenon-enhanced computed tomography (series 3)].
March 1993, No shinkei geka. Neurological surgery,
W D Obrist, and Z Zhang, and H Yonas
Correlation of xenon-enhanced computed tomography-defined cerebral blood flow reactivity and collateral flow patterns.
September 1994, Stroke,
W D Obrist, and Z Zhang, and H Yonas
Imaging local cerebral blood flow by Xenon-enhanced computed tomography--technical optimization procedures.
January 1988, Neuroradiology,
W D Obrist, and Z Zhang, and H Yonas
A simplified method for measuring cerebral blood flow with xenon-enhanced computed tomography.
August 1991, Clinical physics and physiological measurement : an official journal of the Hospital Physicists' Association, Deutsche Gesellschaft fur Medizinische Physik and the European Federation of Organisations for Medical Physics,
Copied contents to your clipboard!