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Cationomycin, isolated from Actinomadura azurea belongs to a large family of carboxylic polyether antibiotics, transporting monovalent cations through membranes by a mobile carrier mechanism, leading globally to an H+, M+ exchange. In this report the cation transporting properties of cationomycin were characterized in large unilamellar vesicles (LUVs) by 23Na- and 39K-NMR. Kinetic studies showed that cationomycin transported potassium more rapidly than sodium, and the more stable complex was formed with potassium at the water/membrane interface. The transport rate constants measured for cationomycin were compared with those obtained for monensin. Cationomycin transports Na+ more slowly than monensin and has a lower stability complex with Na+ because of the lower formation rate for the complex on the membrane surface. Our results show that transport selectivity of cationomycin is in favour of K+ versus Na+ while the reverse situation is observed for monensin. The relationships between the ionophore properties of cationomycin and monensin with their biological activities are discussed.
A M Delort, and
G Jeminet, and
S Sareth, and
F G Riddle
October 1988,
Biochimica et biophysica acta,
A M Delort, and
G Jeminet, and
S Sareth, and
F G Riddle
February 1985,
Proceedings of the National Academy of Sciences of the United States of America,
A M Delort, and
G Jeminet, and
S Sareth, and
F G Riddle
February 1993,
Biophysical journal,
A M Delort, and
G Jeminet, and
S Sareth, and
F G Riddle
September 1983,
Proceedings of the National Academy of Sciences of the United States of America,
A M Delort, and
G Jeminet, and
S Sareth, and
F G Riddle
November 1986,
Biochimica et biophysica acta,
A M Delort, and
G Jeminet, and
S Sareth, and
F G Riddle
April 1979,
FEBS letters,
A M Delort, and
G Jeminet, and
S Sareth, and
F G Riddle
May 1990,
Biochimica et biophysica acta,
A M Delort, and
G Jeminet, and
S Sareth, and
F G Riddle
November 1998,
Biochimica et biophysica acta,
A M Delort, and
G Jeminet, and
S Sareth, and
F G Riddle
January 1994,
Molecular membrane biology,
A M Delort, and
G Jeminet, and
S Sareth, and
F G Riddle
July 1984,
Experientia,
