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Early exercise after experimental myocardial infarction: effect on left ventricular remodeling. 1998

I A Alhaddad, and I Hakim, and F Siddiqi, and E Lagenback, and C Mallavarapu, and V Nethala, and D Mounce, and P L Ross, and E J Brown
Department of Medicine, Bronx Lebanon Hospital Center, New York 10457, USA. alhaddad@pol.net

BACKGROUND The effect of exercise on left ventricular remodeling after myocardial infarction is unclear. The purpose of this investigation was to test whether exercise undertaken during the healing phase of an acute myocardial infarction has an adverse effect on left ventricular remodeling. METHODS Before surgery, rats (n = 94) were allocated randomly to one of four groups: 1) infarct, swimming exercise; 2) infarct, no exercise; 3) sham operation, swimming exercise; 4) sham operation, no exercise. Beginning 1 week after infarction or sham operation, the rats in the exercise groups swam twice daily for 2 weeks. After a deconditioning period of 5 days, the rats were re-anesthetized, hemodynamic measurements were made, and the hearts were fixed for morphometric analysis. RESULTS Swimming exercise had no effect on remodeling of infarcted myocardium. Rats with infarcts in the swimming and no exercise groups had similar infarct thicknesses (1.1 +/- 0.2 mm and 0.8 +/- 0.2 mm respectively; NS), and similar degrees of infarct expansion (expansion index 1.2 +/- 0.3 and 1.4 +/- 0.3 respectively; NS). Swimming exercise also had no effect on remodeling of non-infarcted myocardium. Left ventricular volumes and pressure-volume relationships were similar in exercised and non-exercised infarcted rats. CONCLUSIONS In rats, 2 weeks of swimming exercise, started 1 week after acute experimental myocardial infarction and followed by 5 days of deconditioning, does not have an adverse effect on left ventricular remodeling.

UI MeSH Term Description Entries
D009203 Myocardial Infarction NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION). Cardiovascular Stroke,Heart Attack,Myocardial Infarct,Cardiovascular Strokes,Heart Attacks,Infarct, Myocardial,Infarction, Myocardial,Infarctions, Myocardial,Infarcts, Myocardial,Myocardial Infarctions,Myocardial Infarcts,Stroke, Cardiovascular,Strokes, Cardiovascular
D009206 Myocardium The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow. Muscle, Cardiac,Muscle, Heart,Cardiac Muscle,Myocardia,Cardiac Muscles,Heart Muscle,Heart Muscles,Muscles, Cardiac,Muscles, Heart
D011897 Random Allocation A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects. Randomization,Allocation, Random
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D005081 Exercise Therapy A regimen or plan of physical activities designed and prescribed for specific therapeutic goals. Its purpose is to restore normal musculoskeletal function or to reduce pain caused by diseases or injuries. Rehabilitation Exercise,Remedial Exercise,Therapy, Exercise,Exercise Therapies,Exercise, Rehabilitation,Exercise, Remedial,Exercises, Rehabilitation,Exercises, Remedial,Rehabilitation Exercises,Remedial Exercises,Therapies, Exercise
D005260 Female Females
D006439 Hemodynamics The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM. Hemodynamic
D000704 Analysis of Variance A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable. ANOVA,Analysis, Variance,Variance Analysis,Analyses, Variance,Variance Analyses
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013550 Swimming An activity in which the body is propelled through water by specific movement of the arms and/or the legs. Swimming as propulsion through water by the movement of limbs, tail, or fins of animals is often studied as a form of PHYSICAL EXERTION or endurance.

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