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A morphological study of DNA repair and apoptotic patterns in relationship with cell cycle events was performed on murine erythroleukemia cells. The presence and distribution of DNA replicon sites were evaluated through the BrdU-anti BrdU immunofluorescence and immunogold techniques in light and electron microscopy. Different patterns of labelling and percentages of BrdU positive cells were observed depending on irradiation dose (up to 60 Gy) and time in post-irradiation culture (up to 24 hours). An enlargement of the S phase of the cell cycle was evidenced 18 hours post-irradiation as determined by flow cytometry analysis. The high resolution approach showed that, in spite of several morphological alterations, BrdU labelling was present even in cells displaying early and late apoptotic features.
R Di Pietro, and
L Centurione, and
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M A Centurione, and
G Sanità Di Toppi, and
L Zamai, and
R Rana
July 2019,
FASEB journal : official publication of the Federation of American Societies for Experimental Biology,
R Di Pietro, and
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E Santavenere, and
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G Sanità Di Toppi, and
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R Rana
March 2012,
Nihon rinsho. Japanese journal of clinical medicine,
R Di Pietro, and
L Centurione, and
E Santavenere, and
M A Centurione, and
G Sanità Di Toppi, and
L Zamai, and
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January 1986,
Basic life sciences,
R Di Pietro, and
L Centurione, and
E Santavenere, and
M A Centurione, and
G Sanità Di Toppi, and
L Zamai, and
R Rana
July 2014,
Antioxidants & redox signaling,
R Di Pietro, and
L Centurione, and
E Santavenere, and
M A Centurione, and
G Sanità Di Toppi, and
L Zamai, and
R Rana
April 2011,
Radiation research,
R Di Pietro, and
L Centurione, and
E Santavenere, and
M A Centurione, and
G Sanità Di Toppi, and
L Zamai, and
R Rana
May 2016,
Radiation research,
R Di Pietro, and
L Centurione, and
E Santavenere, and
M A Centurione, and
G Sanità Di Toppi, and
L Zamai, and
R Rana
January 1996,
Advances in space research : the official journal of the Committee on Space Research (COSPAR),
R Di Pietro, and
L Centurione, and
E Santavenere, and
M A Centurione, and
G Sanità Di Toppi, and
L Zamai, and
R Rana
March 1981,
Experimental cell research,
R Di Pietro, and
L Centurione, and
E Santavenere, and
M A Centurione, and
G Sanità Di Toppi, and
L Zamai, and
R Rana
April 2001,
The Japanese journal of physiology,
R Di Pietro, and
L Centurione, and
E Santavenere, and
M A Centurione, and
G Sanità Di Toppi, and
L Zamai, and
R Rana
January 2000,
Postepy higieny i medycyny doswiadczalnej,
