Biomaterial Database

The effect of voluntary hyperventilation on arterial blood gases and gas exchange in patients with chronic obstructive lung disease. 1976

J Müller, and L Radwan

A 2 min test of voluntary hyperventilation (VHV) was performed on 19 patients with chronic obstructive lung disease (COLD) and on eight control subjects. The average decrease in PaCO2 in the patients in this test was 4.6 mmHg (11%) and the average increase in PaO2 was 12.3 mmHg (19.1%). The average decrease of PaCO2 in control subjects was 16.5 mmHg (48.6%) and the average increase in PaO2 was 38.0 mmHg (46.2%). In patients with COLD, PaCO2 changes during VHV correlated significantly with respiratory exchange ratio; the correlation with minute and alveolar ventilation and deltaVO2/deltaVE ratio during VHV was of borderline significance. PaCO2 changes during VHV did not correlate with FEV1 (percent of predicted) or FEV1/VC%. The possible mechanisms of changes in blood gas tensions during and after the end of VHV test are discussed. The VHV test seems to be useful in evaluation of patients with COLD.

UI	MeSH Term	Description	Entries
D008173	Lung Diseases, Obstructive	Any disorder marked by obstruction of conducting airways of the lung. AIRWAY OBSTRUCTION may be acute, chronic, intermittent, or persistent.	Obstructive Lung Diseases,Obstructive Pulmonary Diseases,Lung Disease, Obstructive,Obstructive Lung Disease,Obstructive Pulmonary Disease,Pulmonary Disease, Obstructive,Pulmonary Diseases, Obstructive
D008297	Male		Males
D008451	Maximal Voluntary Ventilation	Measure of the maximum amount of air that can be breathed in and blown out over a sustained interval such as 15 or 20 seconds. Common abbreviations are MVV and MBC.	Maximal Breathing Capacity,MVV (Ventilation),Breathing Capacities, Maximal,Breathing Capacity, Maximal,Capacities, Maximal Breathing,Capacity, Maximal Breathing,Maximal Breathing Capacities,Maximal Voluntary Ventilations,Ventilation, Maximal Voluntary,Ventilations, Maximal Voluntary,Voluntary Ventilation, Maximal,Voluntary Ventilations, Maximal
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D010100	Oxygen	An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.	Dioxygen,Oxygen-16,Oxygen 16
D010313	Partial Pressure	The pressure that would be exerted by one component of a mixture of gases if it were present alone in a container. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Partial Pressures,Pressure, Partial,Pressures, Partial
D012119	Respiration	The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (	Breathing
D012123	Pulmonary Ventilation	The total volume of gas inspired or expired per unit of time, usually measured in liters per minute.	Respiratory Airflow,Ventilation Tests,Ventilation, Pulmonary,Expiratory Airflow,Airflow, Expiratory,Airflow, Respiratory,Test, Ventilation,Tests, Ventilation,Ventilation Test
D002245	Carbon Dioxide	A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.	Carbonic Anhydride,Anhydride, Carbonic,Dioxide, Carbon
D002908	Chronic Disease	Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).	Chronic Condition,Chronic Illness,Chronically Ill,Chronic Conditions,Chronic Diseases,Chronic Illnesses,Condition, Chronic,Disease, Chronic,Illness, Chronic