-transparent.png){kind=logo}
To establish whether loss of heterozygosity (LOH) for chromosome 16q in Wilms' tumours confers an adverse prognosis, DNA from 40 Wilms' tumour/normal pairs were analysed using highly polymorphic microsatellite markers along the length of 16q. Fifteen per cent of tumours showed LOH for 16q. Although the common region of allele loss spanned the 16q24-qter region, a second distinct region of LOH was identified in 16q21. Five out of six tumours showing LOH were either (1) high stage or (2) low stage with unfavourable histology. In addition, there was a higher mortality rate in patients showing LOH for 16q than those that did not. These data strongly support the suggestion that LOH for 16q is associated with an adverse prognosis.
R G Grundy, and
J Pritchard, and
P Scambler, and
J K Cowell
October 2001,
American journal of respiratory and critical care medicine,
R G Grundy, and
J Pritchard, and
P Scambler, and
J K Cowell
June 1990,
Oncogene,
R G Grundy, and
J Pritchard, and
P Scambler, and
J K Cowell
April 1989,
Molecular and cellular biology,
R G Grundy, and
J Pritchard, and
P Scambler, and
J K Cowell
January 1999,
Anticancer research,
R G Grundy, and
J Pritchard, and
P Scambler, and
J K Cowell
June 1992,
Human genetics,
R G Grundy, and
J Pritchard, and
P Scambler, and
J K Cowell
January 1992,
Journal of gastroenterology and hepatology,
R G Grundy, and
J Pritchard, and
P Scambler, and
J K Cowell
January 2000,
British journal of cancer,
R G Grundy, and
J Pritchard, and
P Scambler, and
J K Cowell
May 2004,
World journal of gastroenterology,
R G Grundy, and
J Pritchard, and
P Scambler, and
J K Cowell
March 2001,
Zhonghua yi xue za zhi,
R G Grundy, and
J Pritchard, and
P Scambler, and
J K Cowell
May 2005,
Zhonghua bing li xue za zhi = Chinese journal of pathology,
