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The effect of caffeine on the genotoxicity of several carcinogenic compounds representing various classes of chemicals was investigated in a panel of V79 Chinese hamster cells genetically engineered to express cytochromes P4501A1 and P4501A2 and differing in their expression of N-acetyltransferases. The formation of micronuclei served as genetic endpoint. The results show that caffeine increases the number of micronuclei induced by 2-aminoanthracene several fold in the test cell lines. The lowest concentration of caffeine enhancing 2-aminoanthracene-induced genotoxicity was 100 nM. Caffeine also potentiated the genotoxicity of aflatoxin B1, 2-amino-3-methylimidazo[4,5-f]-quinoline. N-methyl-N-nitro-N-nitrosoguanidine, 1,6-dinitropyrene, and 7,8-diol-benzo[a]pyrene. Overall, caffeine lowered the effective genotoxic concentrations of these agents by a factor of about three. In contrast, the genotoxic effect of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone is markedly decreased in the presence of caffeine. The results indicate that caffeine may modulate the genotoxicity of chemical carcinogens by different mechanisms.
F Kiefer, and
F J Wiebel
January 1985,
Mutation research,
F Kiefer, and
F J Wiebel
May 1993,
Mutation research,
F Kiefer, and
F J Wiebel
June 1984,
Carcinogenesis,
F Kiefer, and
F J Wiebel
June 1992,
Mutation research,
F Kiefer, and
F J Wiebel
October 1978,
Gan,
F Kiefer, and
F J Wiebel
February 1983,
Shigaku = Odontology; journal of Nihon Dental College,
F Kiefer, and
F J Wiebel
January 1985,
Mutation research,
F Kiefer, and
F J Wiebel
May 1977,
Mutation research,
F Kiefer, and
F J Wiebel
August 1979,
Photochemistry and photobiology,
F Kiefer, and
F J Wiebel
April 1978,
Chemico-biological interactions,
