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OBJECTIVE In 1994, an outbreak of echovirus type 33 (EV33) infection occurred in a maternity hospital in Japan. Nine new-born babies were infected, some presenting symptoms of encephalitis or disseminated intravascular coagulopathy. EV33 was isolated from the faeces or cerebrospinal fluid of all seven of the patients sampled, and serum antibody titres against EV33 were significantly elevated in the convalescence phase sera in all cases. METHODS To study what public health situations EV33 may become a serious pathogen for new born babies, serum EV33 antibody positivity in the general population was examined. Sera were obtained 649 samples before the outbreak, and 344 samples after the outbreak from aged 7 days to 65 years old. RESULTS The average positive rate was 12.0% and the rate increased depending on age. Comparison of positive rates before and after this outbreak showed no increase in any age group. However, the positive rate was found to average only 5.6% in persons aged 16-30 years old, including pregnant women. This low positive rate in young adults would result in a lack or only a low level of antibodies in newborn babies. CONCLUSIONS In conclusion, our findings suggest that EV33 infection in the new-born baby with no or low level of maternal neutralizing antibody may cause serious symptoms.
K Sato, and
T Yamashita, and
K Sakae, and
Y Suzuki, and
N Ishikawa, and
Y Nishimura
September 2003,
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
K Sato, and
T Yamashita, and
K Sakae, and
Y Suzuki, and
N Ishikawa, and
Y Nishimura
January 1997,
The Pediatric infectious disease journal,
K Sato, and
T Yamashita, and
K Sakae, and
Y Suzuki, and
N Ishikawa, and
Y Nishimura
May 2003,
Journal of clinical microbiology,
K Sato, and
T Yamashita, and
K Sakae, and
Y Suzuki, and
N Ishikawa, and
Y Nishimura
November 1989,
The Journal of infection,
K Sato, and
T Yamashita, and
K Sakae, and
Y Suzuki, and
N Ishikawa, and
Y Nishimura
June 1983,
Annales de pediatrie,
K Sato, and
T Yamashita, and
K Sakae, and
Y Suzuki, and
N Ishikawa, and
Y Nishimura
January 1979,
Lancet (London, England),
K Sato, and
T Yamashita, and
K Sakae, and
Y Suzuki, and
N Ishikawa, and
Y Nishimura
September 2014,
Archives of virology,
K Sato, and
T Yamashita, and
K Sakae, and
Y Suzuki, and
N Ishikawa, and
Y Nishimura
September 1978,
Lancet (London, England),
K Sato, and
T Yamashita, and
K Sakae, and
Y Suzuki, and
N Ishikawa, and
Y Nishimura
July 1981,
Mayo Clinic proceedings,
K Sato, and
T Yamashita, and
K Sakae, and
Y Suzuki, and
N Ishikawa, and
Y Nishimura
April 1999,
The Pediatric infectious disease journal,
