Biomaterial Database

Axonal arborization of corticostriatal and corticothalamic fibers arising from prelimbic cortex in the rat. 1998

M Lévesque, and A Parent

Laboratoire de neurobiologie, Centre de recherche Université Laval Robert-Giffard, Beauport, Québec, Canada.

This study aimed at elucidating the branching pattern of striatal and thalamic projections arising from prelimbic (Cg3) cortex in the rat. Small pools (5-15 cells) of neurons were microiontophoretically injected with biotin-dextran or biocytin and their labeled axons were individually reconstructed from serial horizontal sections immunostained for calbindin-D28k to delineate striatal patch/matrix compartments. Reconstruction of > 40 axons shows that all Cg3 corticofugal fibers, including corticothalamic axons from layer VI, course through the patch network in the rostromedial sector of the striatum. Corticostriatal projections arise from two types of layer V cells: (i) long-range corticofugal neurons, whose main axons reach the brainstem and/or spinal cord, and (ii) neurons arborizing into both striatum and claustrum, either ipsi-, contra- or bilaterally. The axons of these two types of neurons arborize profusely in striatal patches and only sparsely in the matrix. Layer VI neurons do not arborize in the striatum but target principally the thalamus. The same corticothalamic axon can innervate the anterior, rostral intralaminar and mediodorsal thalamic nuclei. These findings support the concept that no corticofugal fiber system exists that is solely devoted to the striatum. They also shed new light on how neural information from prelimbic cortex is conveyed to various subcortical limbic structures in the rat.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009415	Nerve Net	A meshlike structure composed of interconnecting nerve cells that are separated at the synaptic junction or joined to one another by cytoplasmic processes. In invertebrates, for example, the nerve net allows nerve impulses to spread over a wide area of the net because synapses can pass information in any direction.	Neural Networks (Anatomic),Nerve Nets,Net, Nerve,Nets, Nerve,Network, Neural (Anatomic),Networks, Neural (Anatomic),Neural Network (Anatomic)
D001931	Brain Mapping	Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.	Brain Electrical Activity Mapping,Functional Cerebral Localization,Topographic Brain Mapping,Brain Mapping, Topographic,Functional Cerebral Localizations,Mapping, Brain,Mapping, Topographic Brain
D002540	Cerebral Cortex	The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulci. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions.	Allocortex,Archipallium,Cortex Cerebri,Cortical Plate,Paleocortex,Periallocortex,Allocortices,Archipalliums,Cerebral Cortices,Cortex Cerebrus,Cortex, Cerebral,Cortical Plates,Paleocortices,Periallocortices,Plate, Cortical
D003342	Corpus Striatum	Striped GRAY MATTER and WHITE MATTER consisting of the NEOSTRIATUM and paleostriatum (GLOBUS PALLIDUS). It is located in front of and lateral to the THALAMUS in each cerebral hemisphere. The gray substance is made up of the CAUDATE NUCLEUS and the lentiform nucleus (the latter consisting of the GLOBUS PALLIDUS and PUTAMEN). The WHITE MATTER is the INTERNAL CAPSULE.	Lenticular Nucleus,Lentiform Nucleus,Lentiform Nuclei,Nucleus Lentiformis,Lentiformis, Nucleus,Nuclei, Lentiform,Nucleus, Lenticular,Nucleus, Lentiform,Striatum, Corpus
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001369	Axons	Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body.	Axon
D013788	Thalamus	Paired bodies containing mostly GRAY MATTER and forming part of the lateral wall of the THIRD VENTRICLE of the brain.	Thalamencephalon,Thalamencephalons
D015203	Reproducibility of Results	The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.	Reliability and Validity,Reliability of Result,Reproducibility Of Result,Reproducibility of Finding,Validity of Result,Validity of Results,Face Validity,Reliability (Epidemiology),Reliability of Results,Reproducibility of Findings,Test-Retest Reliability,Validity (Epidemiology),Finding Reproducibilities,Finding Reproducibility,Of Result, Reproducibility,Of Results, Reproducibility,Reliabilities, Test-Retest,Reliability, Test-Retest,Result Reliabilities,Result Reliability,Result Validities,Result Validity,Result, Reproducibility Of,Results, Reproducibility Of,Test Retest Reliability,Validity and Reliability,Validity, Face