Biomaterial Database

Mounting evidence against current histogenetic concepts for salivary gland tumorigenesis. 1998

I Dardick

Dept. Pathology, University of Toronto, Ontario, Canada.

Various morphological observations of salivary gland tumors are frequently used to support histogenetic concepts, such as the semipluripotential bicellular reserve cell hypothesis, for these tumors. Singularly, evidence in support of this hypothesis remains unavailable. Indeed, physiological evidence from studies of salivary glands have long existed proving the semipluripotential bicellular reserve cell hypothesis was incorrect. More recent studies reconfirm this and show that all cell types in these complex glands are quite capable of replication and, therefore, of being involved in tumorigenic processes. The demise of the bicellular reserve cell hypothesis is long overdue.

UI	MeSH Term	Description	Entries
D010306	Parotid Gland	The largest of the three pairs of SALIVARY GLANDS. They lie on the sides of the FACE immediately below and in front of the EAR.	Gland, Parotid,Glands, Parotid,Parotid Glands
D002455	Cell Division	The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.	M Phase,Cell Division Phase,Cell Divisions,Division Phase, Cell,Division, Cell,Divisions, Cell,M Phases,Phase, Cell Division,Phase, M,Phases, M
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012468	Salivary Gland Neoplasms	Tumors or cancer of the SALIVARY GLANDS.	Cancer of Salivary Gland,Non-Sebaceous Lymphadenomas,Salivary Gland Cancer,Salivary Gland Lymphadenomas,Sebaceous Lymphadenomas,Cancer of the Salivary Gland,Neoplasms, Salivary Gland,Cancer, Salivary Gland,Cancers, Salivary Gland,Gland Neoplasm, Salivary,Gland Neoplasms, Salivary,Lymphadenoma, Non-Sebaceous,Lymphadenoma, Salivary Gland,Lymphadenoma, Sebaceous,Lymphadenomas, Non-Sebaceous,Lymphadenomas, Salivary Gland,Lymphadenomas, Sebaceous,Neoplasm, Salivary Gland,Non Sebaceous Lymphadenomas,Non-Sebaceous Lymphadenoma,Salivary Gland Cancers,Salivary Gland Lymphadenoma,Salivary Gland Neoplasm,Sebaceous Lymphadenoma
D018809	Proliferating Cell Nuclear Antigen	Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.	Antigen, Proliferating Cell Nuclear,PCNA
D018987	Salivary Ducts	Any of the ducts which transport saliva. Salivary ducts include the parotid duct, the major and minor sublingual ducts, and the submandibular duct.	Stensen's Duct,Wharton's Duct,Duct, Salivary,Duct, Stensen's,Duct, Wharton's,Ducts, Salivary,Salivary Duct,Stensen Duct,Stensens Duct,Wharton Duct,Whartons Duct