BIOMAT Database Logo BIOMAT Database Logo

Effects of early postnatal dexamethasone therapy on calcium homeostasis and bone growth in preterm infants with respiratory distress syndrome. 1998

Y J Lin, and T F Yeh, and H C Lin, and J M Wu, and C H Lin, and C Y Yu
Department of Pediatrics, National Cheng-Kung University Hospital, Tainan, Taiwan, ROC.

The effects of dexamethasone therapy on calcium homeostasis and bone growth were evaluated in 49 infants (24 placebo and 25 dexamethasone) who participated in a double-blind trial of early dexamethasone therapy for the prevention of chronic lung disease. Dexamethasone (0.25 mg kg(-1) b.i.d. on d 1-7; 0.12 mg kg(-1) b.i.d. on d 8-14; 0.05 mg kg(-1) b.i.d. on d 15-21; 0.02 mg kg(-1) b.i.d. on d 22-28) or saline placebo was given i.v. Serum calcium (Ca), phosphorus (P) and parathyroid hormone (PTH), and the corresponding urinary excretion of calcium (FECa) and phosphorus (FEP) were measured on d 2, 3, 7, 10, 14, 21 and 28 after starting the study. Radiographic evaluations of bone growth were also evaluated. Infants in the dexamethasone group had significantly higher PTH on d 2 (p < 0.01), 7 and 14 (p < 0.05) than infants in the placebo group. The dexamethasone-treated infants also had significantly higher FEP on d 2, 7 and 14 (p < 0.05) and lower FECa on d 7 and 14 (p < 0.05) than control infants. There was no significant difference between the groups in bone growth during the study. It was concluded that early dexamethasone therapy causes a transient elevation in PTH without apparent change in bone growth. The long-term effect remains to be evaluated further.

UI MeSH Term Description Entries
D007231 Infant, Newborn An infant during the first 28 days after birth. Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D007234 Infant, Premature A human infant born before 37 weeks of GESTATION. Neonatal Prematurity,Premature Infants,Preterm Infants,Infant, Preterm,Infants, Premature,Infants, Preterm,Premature Infant,Prematurity, Neonatal,Preterm Infant
D008297 Male Males
D010281 Parathyroid Hormone A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates. Natpara,PTH (1-84),PTH(1-34),Parathormone,Parathyrin,Parathyroid Hormone (1-34),Parathyroid Hormone (1-84),Parathyroid Hormone Peptide (1-34),Hormone, Parathyroid
D012127 Respiratory Distress Syndrome, Newborn A condition of the newborn marked by DYSPNEA with CYANOSIS, heralded by such prodromal signs as dilatation of the alae nasi, expiratory grunt, and retraction of the suprasternal notch or costal margins, mostly frequently occurring in premature infants, children of diabetic mothers, and infants delivered by cesarean section, and sometimes with no apparent predisposing cause. Infantile Respiratory Distress Syndrome,Neonatal Respiratory Distress Syndrome,Respiratory Distress Syndrome, Infant
D001846 Bone Development The growth and development of bones from fetus to adult. It includes two principal mechanisms of bone growth: growth in length of long bones at the epiphyseal cartilages and growth in thickness by depositing new bone (OSTEOGENESIS) with the actions of OSTEOBLASTS and OSTEOCLASTS. Bone Growth
D002118 Calcium A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. Coagulation Factor IV,Factor IV,Blood Coagulation Factor IV,Calcium-40,Calcium 40,Factor IV, Coagulation
D003907 Dexamethasone An anti-inflammatory 9-fluoro-glucocorticoid. Hexadecadrol,Decaject,Decaject-L.A.,Decameth,Decaspray,Dexasone,Dexpak,Hexadrol,Maxidex,Methylfluorprednisolone,Millicorten,Oradexon,Decaject L.A.
D004311 Double-Blind Method A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment. Double-Masked Study,Double-Blind Study,Double-Masked Method,Double Blind Method,Double Blind Study,Double Masked Method,Double Masked Study,Double-Blind Methods,Double-Blind Studies,Double-Masked Methods,Double-Masked Studies,Method, Double-Blind,Method, Double-Masked,Methods, Double-Blind,Methods, Double-Masked,Studies, Double-Blind,Studies, Double-Masked,Study, Double-Blind,Study, Double-Masked
D005260 Female Females

Related Publications

Y J Lin, and T F Yeh, and H C Lin, and J M Wu, and C H Lin, and C Y Yu
Early postnatal dexamethasone therapy in premature infants with severe respiratory distress syndrome: a double-blind, controlled study.
August 1990, The Journal of pediatrics,
Y J Lin, and T F Yeh, and H C Lin, and J M Wu, and C H Lin, and C Y Yu
Role of early postnatal dexamethasone in respiratory distress syndrome.
February 1998, Indian pediatrics,
Y J Lin, and T F Yeh, and H C Lin, and J M Wu, and C H Lin, and C Y Yu
The effect of early dexamethasone administration on bronchopulmonary dysplasia in preterm infants with respiratory distress syndrome.
January 1998, The Journal of pediatrics,
Y J Lin, and T F Yeh, and H C Lin, and J M Wu, and C H Lin, and C Y Yu
Postnatal triiodothyronine concentrations in healthy preterm infants and in infants with respiratory distress syndrome.
July 1977, Pediatric research,
Y J Lin, and T F Yeh, and H C Lin, and J M Wu, and C H Lin, and C Y Yu
Postnatal thyroid hormones for respiratory distress syndrome in preterm infants.
January 2007, The Cochrane database of systematic reviews,
Y J Lin, and T F Yeh, and H C Lin, and J M Wu, and C H Lin, and C Y Yu
Failure of early postnatal dexamethasone to prevent chronic lung disease in infants with respiratory distress syndrome.
January 1996, Archives of disease in childhood. Fetal and neonatal edition,
Y J Lin, and T F Yeh, and H C Lin, and J M Wu, and C H Lin, and C Y Yu
Early Surfactant Therapy for Respiratory Distress Syndrome in Very Preterm Infants.
February 2023, Healthcare (Basel, Switzerland),
Y J Lin, and T F Yeh, and H C Lin, and J M Wu, and C H Lin, and C Y Yu
Postnatal thyroxine administration for idiopathic respiratory distress syndrome in preterm infants.
January 1988, Hormone research,
Y J Lin, and T F Yeh, and H C Lin, and J M Wu, and C H Lin, and C Y Yu
Effects of early dexamethasone therapy on pulmonary fibrogenic mediators and respiratory mechanics in preterm infants.
January 2002, European cytokine network,
Y J Lin, and T F Yeh, and H C Lin, and J M Wu, and C H Lin, and C Y Yu
Neurological adverse effects of early postnatal dexamethasone in very preterm infants.
March 1999, Archives of disease in childhood. Fetal and neonatal edition,
Copied contents to your clipboard!