-transparent.png){kind=logo}
Using fluorescence optical and electron spin resonance spectroscopy, we have investigated the production of superoxide by bovine endothelial nitric oxide synthase (NOS). In contrast to neuronal NOS, the heme moiety is identified as the exclusive source of superoxide production by endothelial NOS. Thus, calmodulin-mediated enzyme regulation affects production of nitric oxide and superoxide simultaneously and inseparably. The balance between the nitric oxide/superoxide reaction pathways may be shifted by addition of exogenous heme-specific agents, such as tetrahydrobiopterin. Our results have direct relevance for the pathophysiology of atherosclerosis.
Related Publications
E Stroes, and
M Hijmering, and
M van Zandvoort, and
R Wever, and
T J Rabelink, and
E E van Faassen
June 2000,
The Journal of biological chemistry,
E Stroes, and
M Hijmering, and
M van Zandvoort, and
R Wever, and
T J Rabelink, and
E E van Faassen
August 1997,
Biochemical and biophysical research communications,
E Stroes, and
M Hijmering, and
M van Zandvoort, and
R Wever, and
T J Rabelink, and
E E van Faassen
March 2005,
Cardiovascular research,
E Stroes, and
M Hijmering, and
M van Zandvoort, and
R Wever, and
T J Rabelink, and
E E van Faassen
August 1998,
Proceedings of the National Academy of Sciences of the United States of America,
E Stroes, and
M Hijmering, and
M van Zandvoort, and
R Wever, and
T J Rabelink, and
E E van Faassen
February 2008,
Biochemistry and cell biology = Biochimie et biologie cellulaire,
E Stroes, and
M Hijmering, and
M van Zandvoort, and
R Wever, and
T J Rabelink, and
E E van Faassen
September 1997,
Biochemistry,
E Stroes, and
M Hijmering, and
M van Zandvoort, and
R Wever, and
T J Rabelink, and
E E van Faassen
September 2018,
Canadian journal of physiology and pharmacology,
E Stroes, and
M Hijmering, and
M van Zandvoort, and
R Wever, and
T J Rabelink, and
E E van Faassen
October 1997,
Hypertension (Dallas, Tex. : 1979),
E Stroes, and
M Hijmering, and
M van Zandvoort, and
R Wever, and
T J Rabelink, and
E E van Faassen
September 2006,
Biochimica et biophysica acta,
E Stroes, and
M Hijmering, and
M van Zandvoort, and
R Wever, and
T J Rabelink, and
E E van Faassen
January 2010,
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology,
