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OBJECTIVE This study aimed to assess the pathologic processes that result in ossification of the cochlear lumen after bacterial meningitis. METHODS The study design was a retrospective case review. METHODS The study was conducted at a tertiary referral center. METHODS Profoundly deaf postmeningitic patients who underwent cochlear implantation were studied. METHODS Diagnostic and therapeutic observations were performed. METHODS The extent of cochlear ossification is classified and related to age at which infection occurred, cerebrospinal fluid leukocyte count, Gram's stain, organism, and delay between meningitis and implantation. The extent of ossification noted on high-definition computed tomographic (CT) scan is compared with surgical findings and related to the time delays between meningitis, imaging, and surgery. RESULTS Ossification fell into three groups: gross ossification of the scala tympani and variable amounts of the scala vestibuli; partial ossification localized to the basal turn of the scala tympani; and no ossification. There was no correlation between the extent of ossification and the age when infected, type of pathogen, cerebrospinal fluid leukocyte count, and time delay between meningitis and implantation. Visualization of bacteria on Gram's stain was a highly sensitive measure of ossification (0.93) but was not specific (0.6) with positive and negative predictive values of 0.76 and 0.86, respectively. High-definition CT underestimated the extent of ossification in 50% of cases when performed within 6 months of meningitis. CONCLUSIONS Ossification is either gross or localized to the basal turn of the scala tympani. If ossification does occur, it is rapid and complete within a few months of infection. The visualization of bacteria on Gram's stain is a sensitive indicator for the presence of ossification but has low specificity. High-definition CT, if performed within the first 6 months of meningitis, can be an inaccurate diagnostic tool and therefore should be performed as close to the date of surgery as possible.
P R Axon, and
R H Temple, and
S R Saeed, and
R T Ramsden
September 1990,
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery,
P R Axon, and
R H Temple, and
S R Saeed, and
R T Ramsden
April 2024,
Journal of personalized medicine,
P R Axon, and
R H Temple, and
S R Saeed, and
R T Ramsden
May 2022,
Acta oto-laryngologica,
P R Axon, and
R H Temple, and
S R Saeed, and
R T Ramsden
January 2016,
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology,
P R Axon, and
R H Temple, and
S R Saeed, and
R T Ramsden
November 2007,
BMJ (Clinical research ed.),
P R Axon, and
R H Temple, and
S R Saeed, and
R T Ramsden
July 2012,
Acta oto-laryngologica,
P R Axon, and
R H Temple, and
S R Saeed, and
R T Ramsden
June 2014,
Pediatrics international : official journal of the Japan Pediatric Society,
P R Axon, and
R H Temple, and
S R Saeed, and
R T Ramsden
April 2014,
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery,
P R Axon, and
R H Temple, and
S R Saeed, and
R T Ramsden
January 1984,
AJNR. American journal of neuroradiology,
P R Axon, and
R H Temple, and
S R Saeed, and
R T Ramsden
May 2007,
Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery,
