-transparent.png){kind=logo}
We studied cerebral blood flow autoregulation by laser Doppler flowmetry, and expression of brain angiotensin II AT1 receptors by quantitative autoradiography, after administration of an angiotensin AT1 receptor antagonist, CV-11974 (Candesartan, 0.5 or 1.0 mg/kg.day) for two weeks via subcutaneously implanted osmotic pumps in adult normotensive Wistar Kyoto and spontaneously hypertensive male rats (SHR). In SHR, the autoregulation curve was shifted towards higher blood pressures, when compared with that of normotensive Wistar Kyoto rats. Administration of CV-11974 shifted the autoregulation curve toward lower blood pressures in both Wistar Kyoto and SHR, partially normalizing the autoregulation curve in SHR. CV-11974 treatment markedly decreased the expression of AT1 receptors in Wistar Kyoto rats, both in areas outside the blood brain barrier (subfornical organ, 95% decrease) and inside the blood brain barrier (nucleus of the tractus solitarius, 87% decrease, and paraventricular nucleus, 96% decrease). Our results demonstrate that blockade of AT1 receptors tends to normalize the shift to higher pressures in the autoregulation curve of genetically hypertensive rats, and has a profound modulatory role in brain angiotensin II AT1 receptors.
Y Nishimura, and
T Xu, and
O Jöhren, and
W Häuser, and
J M Saavedra
July 1995,
Journal of hypertension,
Y Nishimura, and
T Xu, and
O Jöhren, and
W Häuser, and
J M Saavedra
January 1997,
European journal of pharmacology,
Y Nishimura, and
T Xu, and
O Jöhren, and
W Häuser, and
J M Saavedra
January 1994,
Blood pressure. Supplement,
Y Nishimura, and
T Xu, and
O Jöhren, and
W Häuser, and
J M Saavedra
January 1994,
Blood pressure. Supplement,
Y Nishimura, and
T Xu, and
O Jöhren, and
W Häuser, and
J M Saavedra
December 1995,
Hypertension (Dallas, Tex. : 1979),
Y Nishimura, and
T Xu, and
O Jöhren, and
W Häuser, and
J M Saavedra
March 2008,
Digestive diseases and sciences,
Y Nishimura, and
T Xu, and
O Jöhren, and
W Häuser, and
J M Saavedra
July 1993,
Biochemical pharmacology,
Y Nishimura, and
T Xu, and
O Jöhren, and
W Häuser, and
J M Saavedra
February 1994,
European journal of pharmacology,
Y Nishimura, and
T Xu, and
O Jöhren, and
W Häuser, and
J M Saavedra
October 2004,
Journal of human hypertension,
Y Nishimura, and
T Xu, and
O Jöhren, and
W Häuser, and
J M Saavedra
March 2006,
European journal of pharmacology,
