Biomaterial Database

[Polymorphism in alkaline phosphatase (author's transl)]. 1976

I Oepen, and F Müller

1. In horizontal starch-gel electrophoresis placental extracts show an alkaline phosphatase polymorphism which - according to ROBSON and HARRIS - depends on the fetal genotype. Investigations carried out with a series of 73 placentas revealed 5 of the common 6 phenotypes. Their frequencies were in good accordance with the figures published by the English authors. However, there had been difficulties in typing because of obscrue realizing of the patterns. 2. Although there exists a polymorphism of the heart-stable alkaline phosphatase as observed in 66 serum samples from women at delivery, only four types could be distinguished which, however, could not be related to the placental patterns with any certainty. 3. In all but one of 66 samples of cord serum, investigated simultaneously, a single band only could be observed moving at a slower speed than the serum bands of adult pregnant and non-pregnant persons. This is in conformity with the results of the other investigators. 4. In 18 samples of unheated serum the amount of heat-labile alkaline phosphatase was unimportant and did not alter the features of the heat-stable portion of the enzyme. 5. Contrary to expectations, the alkaline phosphatase polymorphism has no medicolegal relevance.

UI	MeSH Term	Description	Entries
D008967	Molecular Biology	A discipline concerned with studying biological phenomena in terms of the chemical and physical interactions of molecules.	Biochemical Genetics,Biology, Molecular,Genetics, Biochemical,Genetics, Molecular,Molecular Genetics,Biochemical Genetic,Genetic, Biochemical,Genetic, Molecular,Molecular Genetic
D010920	Placenta	A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES).	Placentoma, Normal,Placentome,Placentas,Placentomes
D011110	Polymorphism, Genetic	The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.	Gene Polymorphism,Genetic Polymorphism,Polymorphism (Genetics),Genetic Polymorphisms,Gene Polymorphisms,Polymorphism, Gene,Polymorphisms (Genetics),Polymorphisms, Gene,Polymorphisms, Genetic
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D004592	Electrophoresis, Starch Gel	Electrophoresis in which a starch gel (a mixture of amylose and amylopectin) is used as the diffusion medium.	Starch Gel Electrophoresis
D005260	Female		Females
D005838	Genotype	The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.	Genogroup,Genogroups,Genotypes
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000469	Alkaline Phosphatase	An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.1.