-transparent.png){kind=logo}
This study characterizes the echogenicity of experimentally induced venous thrombosis. Venous duplex imaging (Diasonics Spectra) was performed of the rat (n 12) and primate (n 3) inferior vena cava (IVC). Thrombosis was induced by IVC ligation at the level of the renal veins (rat, baboon) or balloon occlusion (baboon) of the IVC at the renal vein and iliac vein bifurcation level. Sham-treated rats served as controls. B-mode images were stored for off-line computer analysis. Fixed depth gain control curves allowed for measuring gain-corrected echogenicity units over the IVC in both a longitudinal and transverse orientation. In rat studies, thrombus was removed at time of euthanasia and dissolved, allowing for fibrin monomer determination using a chromogenic assay. Echogenicity values generally increased over time in both rat and primate studies. Significant differences between ligated and sham-treated rats were noted at each time point measured (6 h, 2 days, and 6 days after IVC ligation) and fibrin monomer values correlated (p < 0.05) with echogenicity units. In primate studies, echogenicity values significantly were different from baseline values at all time points measured (6 h, 2 days, 6 days, and 13 days after thrombus induction). Duplex ultrasound can be used to quantitate thrombus echogenicity, which correlates to fibrin content. Such measurement may potentially allow for improved thrombus age determination and the noninvasive quantitation of thrombus progression/resolution.
J B Fowlkes, and
R M Strieter, and
L J Downing, and
S L Brown, and
A Saluja, and
S Salles-Cunha, and
A M Kadell, and
S K Wrobleski, and
T W Wakefield
August 2003,
Ultraschall in der Medizin (Stuttgart, Germany : 1980),
J B Fowlkes, and
R M Strieter, and
L J Downing, and
S L Brown, and
A Saluja, and
S Salles-Cunha, and
A M Kadell, and
S K Wrobleski, and
T W Wakefield
January 2006,
Thrombosis research,
J B Fowlkes, and
R M Strieter, and
L J Downing, and
S L Brown, and
A Saluja, and
S Salles-Cunha, and
A M Kadell, and
S K Wrobleski, and
T W Wakefield
January 1991,
VASA. Supplementum,
J B Fowlkes, and
R M Strieter, and
L J Downing, and
S L Brown, and
A Saluja, and
S Salles-Cunha, and
A M Kadell, and
S K Wrobleski, and
T W Wakefield
September 1963,
Archives of surgery (Chicago, Ill. : 1960),
J B Fowlkes, and
R M Strieter, and
L J Downing, and
S L Brown, and
A Saluja, and
S Salles-Cunha, and
A M Kadell, and
S K Wrobleski, and
T W Wakefield
October 1991,
Seminars in nuclear medicine,
J B Fowlkes, and
R M Strieter, and
L J Downing, and
S L Brown, and
A Saluja, and
S Salles-Cunha, and
A M Kadell, and
S K Wrobleski, and
T W Wakefield
March 1991,
Deutsche medizinische Wochenschrift (1946),
J B Fowlkes, and
R M Strieter, and
L J Downing, and
S L Brown, and
A Saluja, and
S Salles-Cunha, and
A M Kadell, and
S K Wrobleski, and
T W Wakefield
January 1974,
Thrombosis research,
J B Fowlkes, and
R M Strieter, and
L J Downing, and
S L Brown, and
A Saluja, and
S Salles-Cunha, and
A M Kadell, and
S K Wrobleski, and
T W Wakefield
January 1992,
Seminars in roentgenology,
J B Fowlkes, and
R M Strieter, and
L J Downing, and
S L Brown, and
A Saluja, and
S Salles-Cunha, and
A M Kadell, and
S K Wrobleski, and
T W Wakefield
August 2004,
Emergency medicine clinics of North America,
J B Fowlkes, and
R M Strieter, and
L J Downing, and
S L Brown, and
A Saluja, and
S Salles-Cunha, and
A M Kadell, and
S K Wrobleski, and
T W Wakefield
January 1995,
Annales de cardiologie et d'angeiologie,
